FRINK Linked Data Fragments server

Matches in SemOpenAlex for { <https://semopenalex.org/work/W2485203764> ?p ?o ?g. }

• W2485203764 endingPage "58" @default.
• W2485203764 startingPage "51" @default.
• W2485203764 abstract "The aim of this study was to evaluate the effect of subcutaneous administration of diphenyl diselenide (PhSe)2 on animal behavior and activities of acetylcholinesterase (AChE), adenylate kinase (AK), and creatine kinase (CK) in the brain of mice infected by Toxoplasma gondii. In addition, thiobarbituric acid reactive species (TBARS) levels and glutathione (GR, GPx and GST) activity were also evaluated. For the study, 40 female mice were divided into four groups of 10 animals each: group A (uninfected and untreated), group B (uninfected and treated with (PhSe)2), group C (infected and untreated) and group D (infected and treated with (PhSe)2). The mice were inoculated with 50 cysts of the ME49 strain of T. gondii. After infection the animals of the groups B and D were treated on days 1 and 20 post-infection (PI) with 5.0 μmol/kg of (PhSe)2 subcutaneously. Behavioral tests were conducted on days 29 PI to assess memory loss (object recognition), anxiety (elevated plus maze), locomotor and exploratory activity (Open Field) and it was found out that infected and untreated animals (group C) had developed anxiety and memory impairment, and the (PhSe)2 treatment did not reverse these behavioral changes on infected animals treated with (PhSe)2 (group D). The results showed an increase on AChE activity (P < 0.01) in the brain of infected and untreated animals (group C) compared to the uninfected and untreated animals (group A). The AK and CK activities decreased in infected and untreated animals (group C) compared to the uninfected and untreated animals (group A) (P < 0.01), however the (PhSe)2 treatment did not reverse these alterations. Infected and untreated animals (group C) showed increased TBARS levels and GR activity, and decreased GPx and GST activities when compared to uninfected and untreated animals (group A). Infected animals treated with (PhSe)2 (group D) decreased TBARS levels and GR activity, while increased GST activity when compared to infected and untreated animals (group C). It was concluded that (PhSe)2 showed antioxidant activity, but the dose used had no anti-inflammatory effect and failed to reverse the behavioral changes caused by the parasite." @default.
• W2485203764 created "2016-08-23" @default.
• W2485203764 creator A5001754648 @default.
• W2485203764 creator A5010553534 @default.
• W2485203764 creator A5020503858 @default.
• W2485203764 creator A5022367997 @default.
• W2485203764 creator A5024734755 @default.
• W2485203764 creator A5026105262 @default.
• W2485203764 creator A5032181986 @default.
• W2485203764 creator A5040932536 @default.
• W2485203764 creator A5045131615 @default.
• W2485203764 creator A5063691024 @default.
• W2485203764 creator A5066689763 @default.
• W2485203764 creator A5072297080 @default.
• W2485203764 creator A5072681198 @default.
• W2485203764 creator A5072999640 @default.
• W2485203764 creator A5081050186 @default.
• W2485203764 creator A5083728010 @default.
• W2485203764 creator A5089581600 @default.
• W2485203764 date "2016-10-01" @default.
• W2485203764 modified "2023-10-14" @default.
• W2485203764 title "Diphenyl diselenide supplementation in infected mice by Toxoplasma gondii: Protective effect on behavior, neuromodulation and oxidative stress caused by disease" @default.
• W2485203764 cites W1546369396 @default.
• W2485203764 cites W1581414347 @default.
• W2485203764 cites W1749560786 @default.
• W2485203764 cites W1775749144 @default.
• W2485203764 cites W191630185 @default.
• W2485203764 cites W1969367001 @default.
• W2485203764 cites W1970753345 @default.
• W2485203764 cites W1971048984 @default.
• W2485203764 cites W1976656430 @default.
• W2485203764 cites W1976701283 @default.
• W2485203764 cites W1976889106 @default.
• W2485203764 cites W1983133472 @default.
• W2485203764 cites W1983310681 @default.
• W2485203764 cites W1983588728 @default.
• W2485203764 cites W2002100035 @default.
• W2485203764 cites W2010628456 @default.
• W2485203764 cites W2019657620 @default.
• W2485203764 cites W2025222765 @default.
• W2485203764 cites W2027792962 @default.
• W2485203764 cites W2029302143 @default.
• W2485203764 cites W2029927171 @default.
• W2485203764 cites W2031029755 @default.
• W2485203764 cites W2035664793 @default.
• W2485203764 cites W2041561931 @default.
• W2485203764 cites W2042829142 @default.
• W2485203764 cites W2052513141 @default.
• W2485203764 cites W2055573999 @default.
• W2485203764 cites W2058320183 @default.
• W2485203764 cites W2062550849 @default.
• W2485203764 cites W2066828362 @default.
• W2485203764 cites W2067114364 @default.
• W2485203764 cites W2067651611 @default.
• W2485203764 cites W2072209578 @default.
• W2485203764 cites W2072780035 @default.
• W2485203764 cites W2075214517 @default.
• W2485203764 cites W2082550582 @default.
• W2485203764 cites W2083048709 @default.
• W2485203764 cites W2085917914 @default.
• W2485203764 cites W2089901384 @default.
• W2485203764 cites W2090621408 @default.
• W2485203764 cites W2092282847 @default.
• W2485203764 cites W2126666998 @default.
• W2485203764 cites W2134724878 @default.
• W2485203764 cites W2142713800 @default.
• W2485203764 cites W2146778847 @default.
• W2485203764 cites W2148093745 @default.
• W2485203764 cites W2148607376 @default.
• W2485203764 cites W2152916509 @default.
• W2485203764 cites W2155748853 @default.
• W2485203764 cites W2157171390 @default.
• W2485203764 cites W2166569677 @default.
• W2485203764 cites W2169756811 @default.
• W2485203764 cites W2174987964 @default.
• W2485203764 cites W2197332903 @default.
• W2485203764 cites W2256966273 @default.
• W2485203764 cites W4293247451 @default.
• W2485203764 doi "https://doi.org/10.1016/j.exppara.2016.07.006" @default.
• W2485203764 hasPubMedId "https://pubmed.ncbi.nlm.nih.gov/27472985" @default.
• W2485203764 hasPublicationYear "2016" @default.
• W2485203764 type Work @default.
• W2485203764 sameAs 2485203764 @default.
• W2485203764 citedByCount "25" @default.
• W2485203764 countsByYear W24852037642017 @default.
• W2485203764 countsByYear W24852037642018 @default.
• W2485203764 countsByYear W24852037642019 @default.
• W2485203764 countsByYear W24852037642020 @default.
• W2485203764 countsByYear W24852037642021 @default.
• W2485203764 countsByYear W24852037642022 @default.
• W2485203764 countsByYear W24852037642023 @default.
• W2485203764 crossrefType "journal-article" @default.
• W2485203764 hasAuthorship W2485203764A5001754648 @default.
• W2485203764 hasAuthorship W2485203764A5010553534 @default.
• W2485203764 hasAuthorship W2485203764A5020503858 @default.
• W2485203764 hasAuthorship W2485203764A5022367997 @default.
• W2485203764 hasAuthorship W2485203764A5024734755 @default.
• W2485203764 hasAuthorship W2485203764A5026105262 @default.

• next