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• W2485311493 abstract "ABSTRACT Relaxation of smooth muscle of the gastrointestinal tract reflects the interplay of nitric oxide (NO) and the peptide transmitters, mainly vasoactive intestinal peptide and its homolog, pituitary adenylyl cyclase–activating polypeptide (PACAP). In smooth muscle cells, VIP (and PACAP) interact with cognate seven-transmembrane VPAC2 receptors to generate cAMP and with the single-transmembrane NPR-C to generate NO and cGMP. Concurrent generation of cAMP and cGMP and activation of cAMP-dependent protein kinase (PKA) and cGMP-dependent protein kinase (PKG), respectively, are the physiological norms. Both PKA and PKG act on various downstream targets to inhibit Ca2+ mobilization and MLC20 phosphorylation and, thus, induce muscle relaxation." @default.
• W2485311493 created "2016-08-23" @default.
• W2485311493 creator A5007881152 @default.
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• W2485311493 date "2006-01-01" @default.
• W2485311493 modified "2023-10-18" @default.
• W2485311493 title "Signaling by Vasoactive Intestinal Peptide in Gastrointestinal Smooth Muscle" @default.
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• W2485311493 doi "https://doi.org/10.1016/b978-012369442-3/50161-6" @default.
• W2485311493 hasPublicationYear "2006" @default.
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