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Matches in SemOpenAlex for { <https://semopenalex.org/work/W2485348567> ?p ?o ?g. }

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• W2485348567 abstract "A series of sulfonylurea compounds was designed and synthesized via introducing an alkenyl moiety into the aryl-5 position and most title compounds exhibited enhanced antifungal activities and limited herbicidal activities compared with chlorsulfuron. Then, a CoMSIA calculation for antifungal activities was carried out to establish a 3D-QSAR model in which a cross-validated q(2) of 0.585 and a correlation coefficient r(2) of 0.989 were obtained. The derived model revealed that hydrophobic and electrostatic fields were the two most important factors for antifungal activity. Structure optimization was performed according to the CoMSIA model and compound 9z was found to be as potent as chlorothalonil in vitro against C. cornigerum, the pathogen of the wheat sharp eyespot disease. In order to study the fungicidal mechanism, 9z was successfully docked into yeast AHAS using a flexible molecular docking method and the resulting binding pattern was similar to that of chlorimuron-ethyl, indicating that the antifungal activity of compounds 9 was probably due to the inhibition of fungal AHAS." @default.
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• W2485348567 date "2016-01-01" @default.
• W2485348567 modified "2023-10-16" @default.
• W2485348567 title "Design, synthesis and SAR study of novel sulfonylureas containing an alkenyl moiety" @default.
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• W2485348567 doi "https://doi.org/10.1039/c6ob01555g" @default.
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