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• W2485384893 abstract "The increasing emergence of drug-resistant tuberculosis presents a threat to the effective control of tuberculosis (TB). Rapid detection of drug-resistance is more important than ever to address this scourge. The purpose of this study was to genotypically characterize the first-line antitubercular drug-resistant isolates collected over 11 years in Quebec. The main mutations found in our resistant strains collection (n = 225) include: the S315T substitution in katG (50.2 %), the -15 C/T mutation in the inhA promoter (29 %); the S531L substitution in rpoB (43 %); the deletion 8 bp 446 / + R140S in pncA (72.9 %); the M306I (35.7 %) and M306V (21.4 %) substitutions in embB. Ten of the mutations in katG and 4 mutations identified in pncA were previously undescribed. Screening of mutations conferring resistance to first-line antituberculous drugs using DNA-sequencing approach seems to be feasible and would drastically shorten the time to determine the resistance profile compared to the proportion method." @default.
• W2485384893 created "2016-08-23" @default.
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• W2485384893 date "2016-07-26" @default.
• W2485384893 modified "2023-10-01" @default.
• W2485384893 title "Genotypic characterization of drug resistant Mycobacterium tuberculosis in Quebec, 2002-2012" @default.
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• W2485384893 doi "https://doi.org/10.1186/s12866-016-0786-4" @default.
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