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- W2485387890 abstract "Mild cognitive impairment (MCI) and Alzheimer's disease (AD) are becoming increasingly prevalent as life expectancy increases. This chapter discusses the epidemiology, pathophysiology, clinical features, investigations, use of biomarkers and treatment for MCI and AD. It describes the research that is performed with biomarkers to try to differentiate AD-prodromal MCI patients from those with other types of MCI. The prevalence of MCI increases with age, to approximately 30% of individuals above the age of 85. The pathophysiology of MCI depends on the underlying cause of memory impairment. Evaluation of cognitive complaints starts with a detailed history provided by the patient and an informant. While the diagnosis of definite AD continues to require neuropathological confirmation, the advent of biomarkers allows for increased certainty in the clinical diagnosis. Briefly, for symptoms of depression, anxiety, and agitation, selective serotonin reuptake inhibitors (SSRIs) are preferred, with some evidence for the use of citalopram for agitation." @default.
- W2485387890 created "2016-08-23" @default.
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- W2485387890 date "2016-04-22" @default.
- W2485387890 modified "2023-10-13" @default.
- W2485387890 title "Mild cognitive impairment and Alzheimer's disease" @default.
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- W2485387890 doi "https://doi.org/10.1002/9781118777329.ch39" @default.
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