Matches in SemOpenAlex for { <https://semopenalex.org/work/W2485459871> ?p ?o ?g. }
Showing items 1 to 80 of
80
with 100 items per page.
- W2485459871 abstract "We evaluated the immune responses in 28 patients enrolled in a phase II trial at the National Cancer Institute (NCI). The aim was to investigate the effects of 3 months of androgen deprivation therapy (ADT) with goserelin on the immune responses in patients with biochemical progression of prostate cancer following local definitive therapy. PBMC and sera were collected before treatment and after 3 months. We performed flow cytometry to evaluate the frequencies of subsets of CD4 + and CD8 + T-cells, regulatory T-cells (CD4 + CD25 hi CD127 − FoxP3 + ), MDSCs and CD4 and CD8 recent thymic emigrants. CD4 T-cell proliferation and NK-cell lytic activity were evaluated. Serum samples were analyzed for cytokines, sCD27 and sCD40L. The baseline characteristics were: median age 64 years, testosterone 361 ng/dl, PSA 2.2 ng/ml, PSA-doubling time 7.0 months, and Gleason score 7. After 3 months of ADT we found no significant changes in NK-cell function or frequencies of NK subsets. CD4 + T-cell proliferation decreased slightly. The number of CD4 + effector memory T-cells decreased, but other CD4 subsets were unchanged. The frequencies of CD4 and CD8 recent thymic emigrants did not change. Regulatory T-cells (including the CTLA4 + subset), and the effector:Treg ratio did not change. In contrast, the frequency of granulocytic MDSC decreased (P In conclusion, three months of ADT with goserelin did not alter the immune response in a way that would decrease the likelihood of successful immunotherapy after this treatment. The decreased MDSC and the increased sCD27:sCD40L ratio could indicate a more favorable immune environment. Citation Format: Caroline Jochems, Ravi A. Madan, Romaine I. Fernando, James L. Gulley, Kwong Y. Tsang, Jeffrey Schlom. Analysis of immune responses as a consequence of androgen deprivation therapy in patients with biochemical progression of prostate cancer. [abstract]. In: Proceedings of the 107th Annual Meeting of the American Association for Cancer Research; 2016 Apr 16-20; New Orleans, LA. Philadelphia (PA): AACR; Cancer Res 2016;76(14 Suppl):Abstract nr 1406." @default.
- W2485459871 created "2016-08-23" @default.
- W2485459871 creator A5022840249 @default.
- W2485459871 creator A5038477103 @default.
- W2485459871 creator A5044285326 @default.
- W2485459871 creator A5059931764 @default.
- W2485459871 creator A5070669850 @default.
- W2485459871 creator A5072895454 @default.
- W2485459871 date "2016-07-15" @default.
- W2485459871 modified "2023-09-25" @default.
- W2485459871 title "Abstract 1406: Analysis of immune responses as a consequence of androgen deprivation therapy in patients with biochemical progression of prostate cancer" @default.
- W2485459871 doi "https://doi.org/10.1158/1538-7445.am2016-1406" @default.
- W2485459871 hasPublicationYear "2016" @default.
- W2485459871 type Work @default.
- W2485459871 sameAs 2485459871 @default.
- W2485459871 citedByCount "0" @default.
- W2485459871 crossrefType "proceedings-article" @default.
- W2485459871 hasAuthorship W2485459871A5022840249 @default.
- W2485459871 hasAuthorship W2485459871A5038477103 @default.
- W2485459871 hasAuthorship W2485459871A5044285326 @default.
- W2485459871 hasAuthorship W2485459871A5059931764 @default.
- W2485459871 hasAuthorship W2485459871A5070669850 @default.
- W2485459871 hasAuthorship W2485459871A5072895454 @default.
- W2485459871 hasConcept C121608353 @default.
- W2485459871 hasConcept C126322002 @default.
- W2485459871 hasConcept C143998085 @default.
- W2485459871 hasConcept C16685009 @default.
- W2485459871 hasConcept C167672396 @default.
- W2485459871 hasConcept C203014093 @default.
- W2485459871 hasConcept C2776090121 @default.
- W2485459871 hasConcept C2777701055 @default.
- W2485459871 hasConcept C2777899217 @default.
- W2485459871 hasConcept C2778296632 @default.
- W2485459871 hasConcept C2779727006 @default.
- W2485459871 hasConcept C2780192828 @default.
- W2485459871 hasConcept C71924100 @default.
- W2485459871 hasConcept C79484868 @default.
- W2485459871 hasConcept C8891405 @default.
- W2485459871 hasConceptScore W2485459871C121608353 @default.
- W2485459871 hasConceptScore W2485459871C126322002 @default.
- W2485459871 hasConceptScore W2485459871C143998085 @default.
- W2485459871 hasConceptScore W2485459871C16685009 @default.
- W2485459871 hasConceptScore W2485459871C167672396 @default.
- W2485459871 hasConceptScore W2485459871C203014093 @default.
- W2485459871 hasConceptScore W2485459871C2776090121 @default.
- W2485459871 hasConceptScore W2485459871C2777701055 @default.
- W2485459871 hasConceptScore W2485459871C2777899217 @default.
- W2485459871 hasConceptScore W2485459871C2778296632 @default.
- W2485459871 hasConceptScore W2485459871C2779727006 @default.
- W2485459871 hasConceptScore W2485459871C2780192828 @default.
- W2485459871 hasConceptScore W2485459871C71924100 @default.
- W2485459871 hasConceptScore W2485459871C79484868 @default.
- W2485459871 hasConceptScore W2485459871C8891405 @default.
- W2485459871 hasLocation W24854598711 @default.
- W2485459871 hasOpenAccess W2485459871 @default.
- W2485459871 hasPrimaryLocation W24854598711 @default.
- W2485459871 hasRelatedWork W1245936448 @default.
- W2485459871 hasRelatedWork W1509536560 @default.
- W2485459871 hasRelatedWork W1630218274 @default.
- W2485459871 hasRelatedWork W2349714409 @default.
- W2485459871 hasRelatedWork W2353626248 @default.
- W2485459871 hasRelatedWork W2368452990 @default.
- W2485459871 hasRelatedWork W2379740548 @default.
- W2485459871 hasRelatedWork W2383444237 @default.
- W2485459871 hasRelatedWork W2389843300 @default.
- W2485459871 hasRelatedWork W2390339869 @default.
- W2485459871 hasRelatedWork W2399347951 @default.
- W2485459871 hasRelatedWork W2487876667 @default.
- W2485459871 hasRelatedWork W2561212718 @default.
- W2485459871 hasRelatedWork W2563112719 @default.
- W2485459871 hasRelatedWork W2781958477 @default.
- W2485459871 hasRelatedWork W2955299184 @default.
- W2485459871 hasRelatedWork W2999051750 @default.
- W2485459871 hasRelatedWork W3031640473 @default.
- W2485459871 hasRelatedWork W3047580238 @default.
- W2485459871 hasRelatedWork W3214055345 @default.
- W2485459871 isParatext "false" @default.
- W2485459871 isRetracted "false" @default.
- W2485459871 magId "2485459871" @default.
- W2485459871 workType "article" @default.