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• W2485643186 abstract "HIV-1 transactivator protein (Tat) has been shown to play an important role in HIV-associated neurocognitive disorders. The aim of the present study was to evaluate the relationship between occludin and amyloid-beta (A β ) transfer receptors in human cerebral microvascular endothelial cells (hCMEC/D3) in the context of HIV-1-related pathology. The protein expressions of occludin, receptor for advanced glycation end products (RAGE), and low-density lipoprotein receptor-related protein 1 (LRP1) in hCMEC/D3 cells were examined using western blotting and immunofluorescent staining. The mRNA levels of occludin, RAGE, and LRP1 were measured using quantitative real-time polymerase chain reaction. HIV-1 Tat at 1 µ g/mL and the Rho inhibitor hydroxyfasudil (HF) at 30 µ mol/L, with 24 h exposure, had no significant effect on hCMEC/D3 cell viability. Treatment with HIV-1 Tat protein decreased mRNA and protein levels of occludin and LRP1 and upregulated the expression of RAGE; however, these effects were attenuated by HF. These data suggest that the Rho/ROCK signaling pathway is involved in HIV-1 Tat-mediated changes in occludin, RAGE, and LRP1 in hCMEC/D3 cells. HF may have a beneficial influence by protecting the integrity of the blood-brain barrier and the expression of A β transfer receptors." @default.
• W2485643186 created "2016-08-23" @default.
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• W2485643186 date "2016-01-01" @default.
• W2485643186 modified "2023-10-15" @default.
• W2485643186 title "HIV-1 Tat Regulates Occludin and A<i>β</i>Transfer Receptor Expression in Brain Endothelial Cells via Rho/ROCK Signaling Pathway" @default.
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• W2485643186 doi "https://doi.org/10.1155/2016/4196572" @default.
• W2485643186 hasPubMedCentralId "https://www.ncbi.nlm.nih.gov/pmc/articles/4985576" @default.
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