Matches in SemOpenAlex for { <https://semopenalex.org/work/W2485686527> ?p ?o ?g. }
- W2485686527 endingPage "972" @default.
- W2485686527 startingPage "964" @default.
- W2485686527 abstract "Adverse environmental exposures of mothers during fetal period predispose offspring to a range of age-related diseases earlier in life. Here, we set to determine whether a deregulated epigenetic pattern is similar in young animals whose mothers' nutrition was modulated during fetal growth to that acquired during normal aging in animals. Using a rodent model of maternal undernutrition (UN) or overnutrition (ON), we examined cytosine methylation profiles of liver from young female offspring and compared them to age-matched young controls and aged (20-month-old) animals. HELP-tagging, a genomewide restriction enzyme and sequencing assay demonstrates that fetal exposure to two different maternal diets is associated with nonrandom dysregulation of methylation levels with profiles similar to those seen in normal aging animals and occur in regions mapped to genes relevant to metabolic diseases and aging. Functional consequences were assessed by gene expression at 9 weeks old with more significant changes at 6 months of age. Early developmental exposures to unfavorable maternal diets result in altered methylation profiles and transcriptional dysregulation in Prkcb, Pc, Ncor2, and Smad3 that is also seen with normal aging. These Notch pathway and lipogenesis genes may be useful for prediction of later susceptibility to chronic disease." @default.
- W2485686527 created "2016-08-23" @default.
- W2485686527 creator A5002207908 @default.
- W2485686527 creator A5024626668 @default.
- W2485686527 creator A5032037847 @default.
- W2485686527 creator A5035765034 @default.
- W2485686527 creator A5041061250 @default.
- W2485686527 creator A5052299722 @default.
- W2485686527 creator A5055979731 @default.
- W2485686527 date "2016-07-29" @default.
- W2485686527 modified "2023-09-23" @default.
- W2485686527 title "Advanced aging phenotype is revealed by epigenetic modifications in rat liver after in utero malnutrition" @default.
- W2485686527 cites W1483232554 @default.
- W2485686527 cites W1605642752 @default.
- W2485686527 cites W1966151348 @default.
- W2485686527 cites W1969235931 @default.
- W2485686527 cites W1980926706 @default.
- W2485686527 cites W1984524047 @default.
- W2485686527 cites W1985222897 @default.
- W2485686527 cites W1990855495 @default.
- W2485686527 cites W1998417918 @default.
- W2485686527 cites W1998603632 @default.
- W2485686527 cites W2010533371 @default.
- W2485686527 cites W2015615576 @default.
- W2485686527 cites W2028345214 @default.
- W2485686527 cites W2028418054 @default.
- W2485686527 cites W2049590417 @default.
- W2485686527 cites W2049615818 @default.
- W2485686527 cites W2055281361 @default.
- W2485686527 cites W2055382292 @default.
- W2485686527 cites W2064283198 @default.
- W2485686527 cites W2068212083 @default.
- W2485686527 cites W2070934419 @default.
- W2485686527 cites W2073974662 @default.
- W2485686527 cites W2082710199 @default.
- W2485686527 cites W2091252559 @default.
- W2485686527 cites W2095591310 @default.
- W2485686527 cites W2096594075 @default.
- W2485686527 cites W2096728243 @default.
- W2485686527 cites W2099189368 @default.
- W2485686527 cites W2102093038 @default.
- W2485686527 cites W2102669604 @default.
- W2485686527 cites W2107060225 @default.
- W2485686527 cites W2112919574 @default.
- W2485686527 cites W2116017402 @default.
- W2485686527 cites W2121091193 @default.
- W2485686527 cites W2121836310 @default.
- W2485686527 cites W2127196115 @default.
- W2485686527 cites W2130410032 @default.
- W2485686527 cites W2134555277 @default.
- W2485686527 cites W2136315377 @default.
- W2485686527 cites W2141178265 @default.
- W2485686527 cites W2150313386 @default.
- W2485686527 cites W2152626444 @default.
- W2485686527 cites W2166194564 @default.
- W2485686527 cites W2267668114 @default.
- W2485686527 cites W2274260694 @default.
- W2485686527 doi "https://doi.org/10.1111/acel.12505" @default.
- W2485686527 hasPubMedCentralId "https://www.ncbi.nlm.nih.gov/pmc/articles/5013021" @default.
- W2485686527 hasPubMedId "https://pubmed.ncbi.nlm.nih.gov/27470058" @default.
- W2485686527 hasPublicationYear "2016" @default.
- W2485686527 type Work @default.
- W2485686527 sameAs 2485686527 @default.
- W2485686527 citedByCount "17" @default.
- W2485686527 countsByYear W24856865272017 @default.
- W2485686527 countsByYear W24856865272018 @default.
- W2485686527 countsByYear W24856865272019 @default.
- W2485686527 countsByYear W24856865272020 @default.
- W2485686527 countsByYear W24856865272021 @default.
- W2485686527 crossrefType "journal-article" @default.
- W2485686527 hasAuthorship W2485686527A5002207908 @default.
- W2485686527 hasAuthorship W2485686527A5024626668 @default.
- W2485686527 hasAuthorship W2485686527A5032037847 @default.
- W2485686527 hasAuthorship W2485686527A5035765034 @default.
- W2485686527 hasAuthorship W2485686527A5041061250 @default.
- W2485686527 hasAuthorship W2485686527A5052299722 @default.
- W2485686527 hasAuthorship W2485686527A5055979731 @default.
- W2485686527 hasBestOaLocation W24856865271 @default.
- W2485686527 hasConcept C104317684 @default.
- W2485686527 hasConcept C112672928 @default.
- W2485686527 hasConcept C117717151 @default.
- W2485686527 hasConcept C126322002 @default.
- W2485686527 hasConcept C127716648 @default.
- W2485686527 hasConcept C134018914 @default.
- W2485686527 hasConcept C150194340 @default.
- W2485686527 hasConcept C172680121 @default.
- W2485686527 hasConcept C190727270 @default.
- W2485686527 hasConcept C2778302649 @default.
- W2485686527 hasConcept C2779234561 @default.
- W2485686527 hasConcept C33288867 @default.
- W2485686527 hasConcept C41091548 @default.
- W2485686527 hasConcept C42407357 @default.
- W2485686527 hasConcept C511355011 @default.
- W2485686527 hasConcept C54355233 @default.
- W2485686527 hasConcept C71924100 @default.
- W2485686527 hasConcept C86803240 @default.
- W2485686527 hasConceptScore W2485686527C104317684 @default.
- W2485686527 hasConceptScore W2485686527C112672928 @default.