Matches in SemOpenAlex for { <https://semopenalex.org/work/W2485687066> ?p ?o ?g. }
- W2485687066 abstract "The DNA methyltransferase (DNMT) inhibitor 5-azacytidine (5-aza) causes genomic demethylation to regulate gene expression. However, it remains unclear whether 5-aza affects gene expression and cell fate determination of stem cells. In this study, 5-aza was applied to mouse utricle sensory epithelia-derived progenitor cells (MUCs) to investigate whether 5-aza stimulated MUCs to become sensory hair cells. After treatment, MUCs increased expression of hair cell genes and proteins. The DNA methylation level (indicated by percentage of 5-methylcytosine) showed a 28.57% decrease after treatment, which causes significantly repressed DNMT1 protein expression and DNMT activity. Additionally, FM1-43 permeation assays indicated that the permeability of 5-aza-treated MUCs was similar to that of sensory hair cells, which may result from mechanotransduction channels. This study not only demonstrates a possible epigenetic approach to induce tissue specific stem/progenitor cells to become sensory hair cell-like cells, but also provides a cell model to epigenetically modulate stem cell fate determination." @default.
- W2485687066 created "2016-08-23" @default.
- W2485687066 creator A5015139258 @default.
- W2485687066 creator A5084203148 @default.
- W2485687066 date "2016-08-03" @default.
- W2485687066 modified "2023-09-27" @default.
- W2485687066 title "Epigenetic DNA Demethylation Causes Inner Ear Stem Cell Differentiation into Hair Cell-Like Cells" @default.
- W2485687066 cites W1533305218 @default.
- W2485687066 cites W1551909967 @default.
- W2485687066 cites W1964477632 @default.
- W2485687066 cites W1967064280 @default.
- W2485687066 cites W1983443051 @default.
- W2485687066 cites W1986866765 @default.
- W2485687066 cites W1987503911 @default.
- W2485687066 cites W1993475919 @default.
- W2485687066 cites W1994733275 @default.
- W2485687066 cites W1998617043 @default.
- W2485687066 cites W2002032609 @default.
- W2485687066 cites W2003252429 @default.
- W2485687066 cites W2006591300 @default.
- W2485687066 cites W2009415966 @default.
- W2485687066 cites W2020009566 @default.
- W2485687066 cites W2022321609 @default.
- W2485687066 cites W2023989277 @default.
- W2485687066 cites W2024299195 @default.
- W2485687066 cites W2027849612 @default.
- W2485687066 cites W2033763031 @default.
- W2485687066 cites W2046124242 @default.
- W2485687066 cites W2050071487 @default.
- W2485687066 cites W2051405525 @default.
- W2485687066 cites W2053300095 @default.
- W2485687066 cites W2054041085 @default.
- W2485687066 cites W2063607020 @default.
- W2485687066 cites W2074755401 @default.
- W2485687066 cites W2074977023 @default.
- W2485687066 cites W2078028724 @default.
- W2485687066 cites W2082618404 @default.
- W2485687066 cites W2089603629 @default.
- W2485687066 cites W2089975035 @default.
- W2485687066 cites W2090999212 @default.
- W2485687066 cites W2107684775 @default.
- W2485687066 cites W2110551673 @default.
- W2485687066 cites W2113950481 @default.
- W2485687066 cites W2114540841 @default.
- W2485687066 cites W2126665584 @default.
- W2485687066 cites W2133388337 @default.
- W2485687066 cites W2136962742 @default.
- W2485687066 cites W2144287136 @default.
- W2485687066 cites W2146030653 @default.
- W2485687066 cites W2146724332 @default.
- W2485687066 cites W2156295197 @default.
- W2485687066 cites W2170651583 @default.
- W2485687066 cites W2189137086 @default.
- W2485687066 cites W2270797755 @default.
- W2485687066 cites W4211231308 @default.
- W2485687066 doi "https://doi.org/10.3389/fncel.2016.00185" @default.
- W2485687066 hasPubMedCentralId "https://www.ncbi.nlm.nih.gov/pmc/articles/4971107" @default.
- W2485687066 hasPubMedId "https://pubmed.ncbi.nlm.nih.gov/27536218" @default.
- W2485687066 hasPublicationYear "2016" @default.
- W2485687066 type Work @default.
- W2485687066 sameAs 2485687066 @default.
- W2485687066 citedByCount "13" @default.
- W2485687066 countsByYear W24856870662017 @default.
- W2485687066 countsByYear W24856870662019 @default.
- W2485687066 countsByYear W24856870662020 @default.
- W2485687066 countsByYear W24856870662021 @default.
- W2485687066 countsByYear W24856870662022 @default.
- W2485687066 countsByYear W24856870662023 @default.
- W2485687066 crossrefType "journal-article" @default.
- W2485687066 hasAuthorship W2485687066A5015139258 @default.
- W2485687066 hasAuthorship W2485687066A5084203148 @default.
- W2485687066 hasBestOaLocation W24856870661 @default.
- W2485687066 hasConcept C104317684 @default.
- W2485687066 hasConcept C105702510 @default.
- W2485687066 hasConcept C148738053 @default.
- W2485687066 hasConcept C1491633281 @default.
- W2485687066 hasConcept C150194340 @default.
- W2485687066 hasConcept C153911025 @default.
- W2485687066 hasConcept C16824249 @default.
- W2485687066 hasConcept C175211621 @default.
- W2485687066 hasConcept C190727270 @default.
- W2485687066 hasConcept C201750760 @default.
- W2485687066 hasConcept C2778585322 @default.
- W2485687066 hasConcept C2779979206 @default.
- W2485687066 hasConcept C2780130748 @default.
- W2485687066 hasConcept C28328180 @default.
- W2485687066 hasConcept C41091548 @default.
- W2485687066 hasConcept C54355233 @default.
- W2485687066 hasConcept C86803240 @default.
- W2485687066 hasConcept C95444343 @default.
- W2485687066 hasConceptScore W2485687066C104317684 @default.
- W2485687066 hasConceptScore W2485687066C105702510 @default.
- W2485687066 hasConceptScore W2485687066C148738053 @default.
- W2485687066 hasConceptScore W2485687066C1491633281 @default.
- W2485687066 hasConceptScore W2485687066C150194340 @default.
- W2485687066 hasConceptScore W2485687066C153911025 @default.
- W2485687066 hasConceptScore W2485687066C16824249 @default.
- W2485687066 hasConceptScore W2485687066C175211621 @default.
- W2485687066 hasConceptScore W2485687066C190727270 @default.
- W2485687066 hasConceptScore W2485687066C201750760 @default.