Matches in SemOpenAlex for { <https://semopenalex.org/work/W2485752443> ?p ?o ?g. }
Showing items 1 to 85 of
85
with 100 items per page.
- W2485752443 endingPage "276a" @default.
- W2485752443 startingPage "276a" @default.
- W2485752443 abstract "We recently reported significant alterations of mouse cardiac function caused by a mutation (D73N) in cardiac troponin C (TnC) that results in reduced calcium affinity (McConnell et al., Front. Striated Mus. Physiol., doi.org/10.3389/fphys.2015.00242). Many of the cardiac alterations resemble the pathophysiology associated with dilated cardiomyopathy. The heart and slow fibers in skeletal muscle normally express the same isoform of TnC. We, therefore, tested whether the contractile properties of the soleus muscle in mice with the same TnC mutation are altered. Intact soleus muscles were isolated from wild type (WT) and heterozygous knock-in (D73N) mice and contractile properties were measured. Peak forces during isometric twitches and tetani, normalized with muscle cross-sectional area, did not differ between WT and D73N muscles. The times to peak twitch force and to one-half relaxation during twitches and tetani were significantly shorter in D73N muscles. There was a significantly greater reduction in force, over a two-minute fatigue test, in D73N muscles. The force/pCa relationship was measured in skinned slow fibers from the soleus of WT and D73N mice. The pCa50 of the force/pCa curve was significantly different between WT and D73N slow fibers (mean ± SEM: 6.47 ± 0.04 and 6.02 ± 0.02, respectively).The results demonstrate that a mutation in TnC that leads to dilated cardiomyopathy can also induce profound alterations in skeletal muscle function, potentially exacerbating the morbidity associated with cardiomyopathy." @default.
- W2485752443 created "2016-08-23" @default.
- W2485752443 creator A5005403838 @default.
- W2485752443 creator A5015842088 @default.
- W2485752443 creator A5075518537 @default.
- W2485752443 date "2016-02-01" @default.
- W2485752443 modified "2023-09-30" @default.
- W2485752443 title "Consequences of Reduced Troponin-C Calcium Binding Affinity on Slow Skeletal Muscle" @default.
- W2485752443 doi "https://doi.org/10.1016/j.bpj.2015.11.1498" @default.
- W2485752443 hasPublicationYear "2016" @default.
- W2485752443 type Work @default.
- W2485752443 sameAs 2485752443 @default.
- W2485752443 citedByCount "0" @default.
- W2485752443 crossrefType "journal-article" @default.
- W2485752443 hasAuthorship W2485752443A5005403838 @default.
- W2485752443 hasAuthorship W2485752443A5015842088 @default.
- W2485752443 hasAuthorship W2485752443A5075518537 @default.
- W2485752443 hasBestOaLocation W24857524431 @default.
- W2485752443 hasConcept C103486182 @default.
- W2485752443 hasConcept C111566952 @default.
- W2485752443 hasConcept C126322002 @default.
- W2485752443 hasConcept C133927893 @default.
- W2485752443 hasConcept C134018914 @default.
- W2485752443 hasConcept C185592680 @default.
- W2485752443 hasConcept C2776104385 @default.
- W2485752443 hasConcept C2776383484 @default.
- W2485752443 hasConcept C2778198053 @default.
- W2485752443 hasConcept C2778797674 @default.
- W2485752443 hasConcept C2778996579 @default.
- W2485752443 hasConcept C2779959927 @default.
- W2485752443 hasConcept C36036425 @default.
- W2485752443 hasConcept C500558357 @default.
- W2485752443 hasConcept C519063684 @default.
- W2485752443 hasConcept C71924100 @default.
- W2485752443 hasConcept C86803240 @default.
- W2485752443 hasConcept C8880881 @default.
- W2485752443 hasConceptScore W2485752443C103486182 @default.
- W2485752443 hasConceptScore W2485752443C111566952 @default.
- W2485752443 hasConceptScore W2485752443C126322002 @default.
- W2485752443 hasConceptScore W2485752443C133927893 @default.
- W2485752443 hasConceptScore W2485752443C134018914 @default.
- W2485752443 hasConceptScore W2485752443C185592680 @default.
- W2485752443 hasConceptScore W2485752443C2776104385 @default.
- W2485752443 hasConceptScore W2485752443C2776383484 @default.
- W2485752443 hasConceptScore W2485752443C2778198053 @default.
- W2485752443 hasConceptScore W2485752443C2778797674 @default.
- W2485752443 hasConceptScore W2485752443C2778996579 @default.
- W2485752443 hasConceptScore W2485752443C2779959927 @default.
- W2485752443 hasConceptScore W2485752443C36036425 @default.
- W2485752443 hasConceptScore W2485752443C500558357 @default.
- W2485752443 hasConceptScore W2485752443C519063684 @default.
- W2485752443 hasConceptScore W2485752443C71924100 @default.
- W2485752443 hasConceptScore W2485752443C86803240 @default.
- W2485752443 hasConceptScore W2485752443C8880881 @default.
- W2485752443 hasIssue "3" @default.
- W2485752443 hasLocation W24857524431 @default.
- W2485752443 hasOpenAccess W2485752443 @default.
- W2485752443 hasPrimaryLocation W24857524431 @default.
- W2485752443 hasRelatedWork W1582847673 @default.
- W2485752443 hasRelatedWork W1966846717 @default.
- W2485752443 hasRelatedWork W1975559876 @default.
- W2485752443 hasRelatedWork W1983090416 @default.
- W2485752443 hasRelatedWork W1984121364 @default.
- W2485752443 hasRelatedWork W1994712695 @default.
- W2485752443 hasRelatedWork W2015686095 @default.
- W2485752443 hasRelatedWork W2050217519 @default.
- W2485752443 hasRelatedWork W2053449294 @default.
- W2485752443 hasRelatedWork W2065894275 @default.
- W2485752443 hasRelatedWork W2066094116 @default.
- W2485752443 hasRelatedWork W2105241536 @default.
- W2485752443 hasRelatedWork W2151218235 @default.
- W2485752443 hasRelatedWork W2168331764 @default.
- W2485752443 hasRelatedWork W2173676437 @default.
- W2485752443 hasRelatedWork W2341538274 @default.
- W2485752443 hasRelatedWork W2413613839 @default.
- W2485752443 hasRelatedWork W2435026729 @default.
- W2485752443 hasRelatedWork W2563728375 @default.
- W2485752443 hasRelatedWork W2889600597 @default.
- W2485752443 hasVolume "110" @default.
- W2485752443 isParatext "false" @default.
- W2485752443 isRetracted "false" @default.
- W2485752443 magId "2485752443" @default.
- W2485752443 workType "article" @default.