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- W2485821502 abstract "In the nematode Caenorhabditis elegans, inactivating mutations in the insulin/IGF-1 receptor, DAF-2, result in a 2-fold increase in lifespan mediated by DAF-16, a FOXO-family transcription factor. Downstream protein activities that directly regulate longevity during impaired insulin/IGF-1 signaling (IIS) are poorly characterized. Here, we use global cysteine-reactivity profiling to identify protein activity changes during impaired IIS. Upon confirming that cysteine reactivity is a good predictor of functionality in C. elegans, we profiled cysteine-reactivity changes between daf-2 and daf-16;daf-2 mutants, and identified 40 proteins that display a >2-fold change. Subsequent RNAi-mediated knockdown studies revealed that lbp-3 and K02D7.1 knockdown caused significant increases in lifespan and dauer formation. The proteins encoded by these two genes, LBP-3 and K02D7.1, are implicated in intracellular fatty acid transport and purine metabolism, respectively. These studies demonstrate that cysteine-reactivity profiling can be complementary to abundance-based transcriptomic and proteomic studies, serving to identify uncharacterized mediators of C. elegans longevity." @default.
- W2485821502 created "2016-08-23" @default.
- W2485821502 creator A5010463049 @default.
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- W2485821502 creator A5041061046 @default.
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- W2485821502 creator A5044941998 @default.
- W2485821502 date "2016-08-01" @default.
- W2485821502 modified "2023-10-17" @default.
- W2485821502 title "Global Cysteine-Reactivity Profiling during Impaired Insulin/IGF-1 Signaling in C. elegans Identifies Uncharacterized Mediators of Longevity" @default.
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- W2485821502 cites W1631908837 @default.
- W2485821502 cites W1877188956 @default.
- W2485821502 cites W1964701096 @default.
- W2485821502 cites W1965684670 @default.
- W2485821502 cites W1967103312 @default.
- W2485821502 cites W1968681647 @default.
- W2485821502 cites W1969725278 @default.
- W2485821502 cites W1972168184 @default.
- W2485821502 cites W1975006428 @default.
- W2485821502 cites W1976810340 @default.
- W2485821502 cites W1977943199 @default.
- W2485821502 cites W1978503253 @default.
- W2485821502 cites W1987120082 @default.
- W2485821502 cites W1991080848 @default.
- W2485821502 cites W1992444358 @default.
- W2485821502 cites W1992843897 @default.
- W2485821502 cites W1997052628 @default.
- W2485821502 cites W2001462701 @default.
- W2485821502 cites W2004117621 @default.
- W2485821502 cites W2006591185 @default.
- W2485821502 cites W2006732267 @default.
- W2485821502 cites W2006842959 @default.
- W2485821502 cites W2013388821 @default.
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- W2485821502 cites W2023431124 @default.
- W2485821502 cites W2027977649 @default.
- W2485821502 cites W2028161249 @default.
- W2485821502 cites W2028964260 @default.
- W2485821502 cites W2034349959 @default.
- W2485821502 cites W2034911893 @default.
- W2485821502 cites W2038492783 @default.
- W2485821502 cites W2038825874 @default.
- W2485821502 cites W2038977009 @default.
- W2485821502 cites W2040056656 @default.
- W2485821502 cites W2043829280 @default.
- W2485821502 cites W2046989794 @default.
- W2485821502 cites W2051444362 @default.
- W2485821502 cites W2052722944 @default.
- W2485821502 cites W2052741765 @default.
- W2485821502 cites W2057225928 @default.
- W2485821502 cites W2061431107 @default.
- W2485821502 cites W2064390078 @default.
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- W2485821502 cites W2073964546 @default.
- W2485821502 cites W2075883751 @default.
- W2485821502 cites W2077612844 @default.
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- W2485821502 cites W2107996007 @default.
- W2485821502 cites W2121867223 @default.
- W2485821502 cites W2126593560 @default.
- W2485821502 cites W2130973560 @default.
- W2485821502 cites W2142251647 @default.
- W2485821502 cites W2142305917 @default.
- W2485821502 cites W2142558537 @default.
- W2485821502 cites W2145662716 @default.
- W2485821502 cites W2147073885 @default.
- W2485821502 cites W2159940458 @default.
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- W2485821502 cites W2166371252 @default.
- W2485821502 cites W2170363318 @default.
- W2485821502 cites W2172214973 @default.
- W2485821502 cites W2315466337 @default.
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- W2485821502 doi "https://doi.org/10.1016/j.chembiol.2016.06.015" @default.
- W2485821502 hasPubMedCentralId "https://www.ncbi.nlm.nih.gov/pmc/articles/5003114" @default.
- W2485821502 hasPubMedId "https://pubmed.ncbi.nlm.nih.gov/27499530" @default.
- W2485821502 hasPublicationYear "2016" @default.
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