Matches in SemOpenAlex for { <https://semopenalex.org/work/W2485851569> ?p ?o ?g. }
Showing items 1 to 60 of
60
with 100 items per page.
- W2485851569 endingPage "5" @default.
- W2485851569 startingPage "171" @default.
- W2485851569 abstract "Heparin is mainly known for its anticoagulant action, but today other biological effects are investigated. With the low molecular weight heparin fractions (LMWH), more homogenous, a more detailed study of the mechanism of action of heparins can be made. The anticoagulant action of heparin is mainly antithrombin III (AT III) dependent and the binding site of AT III on the heparin molecule has been recently identified. LMWH have a lower anticoagulant (anti-IIa) activity, and a relatively higher anti-Xa activity (ratio anti-Xa/anti-IIa = 5 to 10 for LMWH and 1 for standard heparin). The antithrombotic action of heparins is not strictly correlated to their anticoagulant activity. Other mechanisms of action, such as interactions with vascular endothelial cells and the fibrinolytic system may contribute to the antithrombotic action of heparins. New therapeutical possibilities are currently under investigation. Inhibition of vascular smooth muscle cells growth by heparin suggest a possible control of the atherosclerotic process by heparin. Moreover, heparin and its derivatives might be involved in the regulation of the cellular growth process." @default.
- W2485851569 created "2016-08-23" @default.
- W2485851569 creator A5021981893 @default.
- W2485851569 creator A5089167563 @default.
- W2485851569 date "1987-01-01" @default.
- W2485851569 modified "2023-10-14" @default.
- W2485851569 title "[From heparin to heparins: toward new therapeutic perspectives?]." @default.
- W2485851569 hasPubMedId "https://pubmed.ncbi.nlm.nih.gov/3620582" @default.
- W2485851569 hasPublicationYear "1987" @default.
- W2485851569 type Work @default.
- W2485851569 sameAs 2485851569 @default.
- W2485851569 citedByCount "1" @default.
- W2485851569 crossrefType "journal-article" @default.
- W2485851569 hasAuthorship W2485851569A5021981893 @default.
- W2485851569 hasAuthorship W2485851569A5089167563 @default.
- W2485851569 hasConcept C126322002 @default.
- W2485851569 hasConcept C185592680 @default.
- W2485851569 hasConcept C202751555 @default.
- W2485851569 hasConcept C2776120743 @default.
- W2485851569 hasConcept C2776884760 @default.
- W2485851569 hasConcept C2777015399 @default.
- W2485851569 hasConcept C2777557582 @default.
- W2485851569 hasConcept C2778205648 @default.
- W2485851569 hasConcept C2779026020 @default.
- W2485851569 hasConcept C55493867 @default.
- W2485851569 hasConcept C71924100 @default.
- W2485851569 hasConcept C98274493 @default.
- W2485851569 hasConceptScore W2485851569C126322002 @default.
- W2485851569 hasConceptScore W2485851569C185592680 @default.
- W2485851569 hasConceptScore W2485851569C202751555 @default.
- W2485851569 hasConceptScore W2485851569C2776120743 @default.
- W2485851569 hasConceptScore W2485851569C2776884760 @default.
- W2485851569 hasConceptScore W2485851569C2777015399 @default.
- W2485851569 hasConceptScore W2485851569C2777557582 @default.
- W2485851569 hasConceptScore W2485851569C2778205648 @default.
- W2485851569 hasConceptScore W2485851569C2779026020 @default.
- W2485851569 hasConceptScore W2485851569C55493867 @default.
- W2485851569 hasConceptScore W2485851569C71924100 @default.
- W2485851569 hasConceptScore W2485851569C98274493 @default.
- W2485851569 hasIssue "4" @default.
- W2485851569 hasLocation W24858515691 @default.
- W2485851569 hasOpenAccess W2485851569 @default.
- W2485851569 hasPrimaryLocation W24858515691 @default.
- W2485851569 hasRelatedWork W1980710331 @default.
- W2485851569 hasRelatedWork W2005984490 @default.
- W2485851569 hasRelatedWork W2068218382 @default.
- W2485851569 hasRelatedWork W2093491931 @default.
- W2485851569 hasRelatedWork W2120090098 @default.
- W2485851569 hasRelatedWork W2149191816 @default.
- W2485851569 hasRelatedWork W2154004742 @default.
- W2485851569 hasRelatedWork W2485851569 @default.
- W2485851569 hasRelatedWork W2550737813 @default.
- W2485851569 hasRelatedWork W2945269391 @default.
- W2485851569 hasVolume "41" @default.
- W2485851569 isParatext "false" @default.
- W2485851569 isRetracted "false" @default.
- W2485851569 magId "2485851569" @default.
- W2485851569 workType "article" @default.