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- W2485923553 abstract "Cellular signaling events are initiated by the interaction of agonists with specific cellular receptors. However, agonists do not uniformly activate all cellular signaling events in all cellular systems. This phenomenon has been termed ligand or agonist bias. Classical models to explain and measure ligand bias in cell surface receptors assume this phenomenon is the consequence of agonist-selective stabilization of specific conformational states of the receptor. However, signaling phenomena are critically influenced by the intracellular context and the tissue microenvironment. Cell surface receptors are often associated with other receptors and multiple regulatory proteins, which leads to crosstalk between different pathways and signaling switches from one signaling pathway to another. Furthermore, cells exist in close proximity to other cells, and the crosstalk between different cell types critically influences the outcome of specific signaling processes. This chapter presents an overview of the mechanisms by which the intra- and extra-cellular environments modulate responses to selected stimuli. The review focuses on two receptor superfamilies: the G protein coupled receptors and the receptor tyrosine kinases." @default.
- W2485923553 created "2016-08-23" @default.
- W2485923553 creator A5020551704 @default.
- W2485923553 date "2014-01-01" @default.
- W2485923553 modified "2023-10-16" @default.
- W2485923553 title "The Role of the Cell Background in Biased Signaling" @default.
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