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- W2485962443 endingPage "874" @default.
- W2485962443 startingPage "857" @default.
- W2485962443 abstract "DFP (diisopropylfluorophosphate; (C3H7)2-P(O)-F) is a dialkylfluorophosphate synthesized in the 1930s by procedures patented for insecticides, mold control, warfare agents, and fluorine compounds for dental protection. However, DFP has never been produced for chemical warfare and is not used as an insecticide. It has been extensively used in research as a model compound of an acetylcholinesterase inhibitor and in other toxicological, pharmacological and biomedical studies. The main chemical reactivity is based on the nucleophilic reaction in the P═O group, with fluoride as the leaving group. This chemical property is the basis for the following: spontaneous degradation in water; the hydrolysis by A-esterases as the enzyme DFPase (not present in humans); and the binding to B-type esterases as the tyrosine residue of albumin and the serine residue on cholinesterases, neuropathy target esterase, serin proteases, and other unidentified esterases. These reactions can explain its biodegradation and toxicity properties. The lower toxicity of DFP in mammals compared with other F-containing nerve agents makes it suitable as a model compound for research studies of biotransformation, toxicity, therapy, and biotechnological disposal of F-containing nerve agents." @default.
- W2485962443 created "2016-08-23" @default.
- W2485962443 creator A5050333703 @default.
- W2485962443 creator A5050990977 @default.
- W2485962443 creator A5068999361 @default.
- W2485962443 date "2015-01-01" @default.
- W2485962443 modified "2023-09-25" @default.
- W2485962443 title "Toxicokinetics and Toxicodynamics of DFP" @default.
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