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- W2486013110 abstract "e19537 Background: DLBCL is a heterogenous disease in terms of outcome. Cell of origin is felt to be one of the most important predictors of outcome to therapy, with better outcome in germinal center B-cell-like (GCB) subtypes compared to non-GCB. Gene expression profiling (GEP) is the gold standard for determining cell of origin, however this is not widely available. Therefore, IHC algorithms have been developed as a surrogate to GEP in determining cell of origin. Several IHC algorithms have been reported, first by Hans et al. Later, refined by Choi, the algorithm incorporated new IHC markers such as GCET1. We report the use of a modified algorithm developed at our institution (UIHC), using IRF8 in place of GCET1, to predict overall survival (OS) and event free survival (EFS). Methods: A subset of UIHC pts (n=52) with DLBCL prospectively enrolled between 11/14/02 and 10/31/07 in the University of Iowa/Mayo Clinic SPORE Molecular Epidemiology Resource were evaluated. Tissue sections were stained with anti..." @default.
- W2486013110 created "2016-08-23" @default.
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- W2486013110 date "2014-05-20" @default.
- W2486013110 modified "2023-09-26" @default.
- W2486013110 title "A novel immunohistochemistry (IHC) algorithm for assigning cell of origin status in diffuse large B-cell lymphoma (DLBCL) that better predicts survival as compared to the Hans algorithm." @default.
- W2486013110 doi "https://doi.org/10.1200/jco.2014.32.15_suppl.e19537" @default.
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