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- W2486019504 abstract "Phytochemical investigation of the flowers of Inula japonica led to isolation of nine sesquiterpenoids, inujaponins A-I, as well as eighteen known ones. These sesquiterpenoids belong to six skeletal-types, including eudesmane, 1,10-seco-eudesmane, germacrane, guaiane, 4,5-seco-guaiane, and pseudoguaiane sesquiterpenoids. Their structures were established by extensive spectroscopic analysis. The absolute configurations of inujaponin A, eupatolide, and deacetylovatifolin were determined by Cu-Kα X-ray crystallographic analysis. Most of the isolated compounds exhibited potent cytotoxicity against HL-60, SMMC-7721, A-549, MCF-7, and SW-480 cancer cell lines, with IC50 values ranging from 1.57 to 22.58 μM. Some selected compounds also possessed significant inhibitory activity against LPS-induced NO production in RAW264.7 macrophages with IC50 values ranging from 1.42 to 8.99 μM." @default.
- W2486019504 created "2016-08-23" @default.
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- W2486019504 date "2016-09-01" @default.
- W2486019504 modified "2023-10-16" @default.
- W2486019504 title "Bioactive sesquiterpenoids from the flowers of Inula japonica" @default.
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- W2486019504 doi "https://doi.org/10.1016/j.phytochem.2016.07.008" @default.
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