FRINK Linked Data Fragments server

Matches in SemOpenAlex for { <https://semopenalex.org/work/W2486133097> ?p ?o ?g. }

• W2486133097 endingPage "18" @default.
• W2486133097 startingPage "8" @default.
• W2486133097 abstract "Peptide inter-domain linkers are peptide segments covalently linking two adjacent domains within a protein. Linkers play a variety of structural and functional roles in naturally occurring proteins. In this work we analyze the sequence properties of the predicted linker regions of the bacterial transcriptional regulators belonging to the recently discovered MocR subfamily of the GntR regulators. Analyses were carried out on the MocR sequences taken from the phyla Actinobacteria, Firmicutes, Alpha-, Beta- and Gammaproteobacteria. The results suggest that MocR linkers display phylum-specific characteristics and unique features different from those already described for other classes of inter-domain linkers. They show an average length significantly higher: 31.8 ± 14.3 residues reaching a maximum of about 150 residues. Compositional propensities displayed general and phylum-specific trends. Pro is dominating in all linkers. Dyad propensity analysis indicate Pro–Pro as the most frequent amino acid pair in all linkers. Physicochemical properties of the linker regions were assessed using amino acid indices relative to different features: in general, MocR linkers are flexible, hydrophilic and display propensity for β-turn or coil conformations. Linker sequences are hypervariable: only similarities between MocR linkers from organisms related at the level of species or genus could be found with sequence searches. The results shed light on the properties of the linker regions of the new MocR subfamily of bacterial regulators and may provide knowledge-based rules for designing artificial linkers with desired properties." @default.
• W2486133097 created "2016-08-23" @default.
• W2486133097 creator A5012247970 @default.
• W2486133097 creator A5015890126 @default.
• W2486133097 creator A5068344981 @default.
• W2486133097 creator A5075305488 @default.
• W2486133097 creator A5078917080 @default.
• W2486133097 creator A5086546981 @default.
• W2486133097 date "2016-12-01" @default.
• W2486133097 modified "2023-10-16" @default.
• W2486133097 title "Structural properties of the linkers connecting the N- and C- terminal domains in the MocR bacterial transcriptional regulators" @default.
• W2486133097 cites W1489523425 @default.
• W2486133097 cites W1722029454 @default.
• W2486133097 cites W1733174267 @default.
• W2486133097 cites W1752267321 @default.
• W2486133097 cites W1976576122 @default.
• W2486133097 cites W1978326932 @default.
• W2486133097 cites W1982475999 @default.
• W2486133097 cites W1982858739 @default.
• W2486133097 cites W1987583739 @default.
• W2486133097 cites W1988298124 @default.
• W2486133097 cites W1996423252 @default.
• W2486133097 cites W1999728411 @default.
• W2486133097 cites W2003300391 @default.
• W2486133097 cites W2005116846 @default.
• W2486133097 cites W2005501403 @default.
• W2486133097 cites W2007893714 @default.
• W2486133097 cites W2013383836 @default.
• W2486133097 cites W2014731953 @default.
• W2486133097 cites W2017545024 @default.
• W2486133097 cites W2017999056 @default.
• W2486133097 cites W2019284852 @default.
• W2486133097 cites W2026649417 @default.
• W2486133097 cites W2029476353 @default.
• W2486133097 cites W2043338013 @default.
• W2486133097 cites W2050135038 @default.
• W2486133097 cites W2062915105 @default.
• W2486133097 cites W2089528382 @default.
• W2486133097 cites W2097606916 @default.
• W2486133097 cites W2105422109 @default.
• W2486133097 cites W2110407472 @default.
• W2486133097 cites W2111520150 @default.
• W2486133097 cites W2115958650 @default.
• W2486133097 cites W2117746967 @default.
• W2486133097 cites W2120172561 @default.
• W2486133097 cites W2120772351 @default.
• W2486133097 cites W2121151853 @default.
• W2486133097 cites W2122581494 @default.
• W2486133097 cites W2126719129 @default.
• W2486133097 cites W2126742032 @default.
• W2486133097 cites W2127322768 @default.
• W2486133097 cites W2132629607 @default.
• W2486133097 cites W2133661231 @default.
• W2486133097 cites W2134353698 @default.
• W2486133097 cites W2140628140 @default.
• W2486133097 cites W2142284828 @default.
• W2486133097 cites W2143251450 @default.
• W2486133097 cites W2145233296 @default.
• W2486133097 cites W2149653886 @default.
• W2486133097 cites W2151831732 @default.
• W2486133097 cites W2153544371 @default.
• W2486133097 cites W2157336072 @default.
• W2486133097 cites W2158714788 @default.
• W2486133097 cites W2161425107 @default.
• W2486133097 cites W2164260969 @default.
• W2486133097 cites W2168909138 @default.
• W2486133097 cites W2169701242 @default.
• W2486133097 cites W2179704358 @default.
• W2486133097 cites W2508155194 @default.
• W2486133097 cites W36629840 @default.
• W2486133097 cites W395106337 @default.
• W2486133097 cites W4213345021 @default.
• W2486133097 doi "https://doi.org/10.1016/j.biopen.2016.07.002" @default.
• W2486133097 hasPubMedCentralId "https://www.ncbi.nlm.nih.gov/pmc/articles/5801912" @default.
• W2486133097 hasPubMedId "https://pubmed.ncbi.nlm.nih.gov/29450126" @default.
• W2486133097 hasPublicationYear "2016" @default.
• W2486133097 type Work @default.
• W2486133097 sameAs 2486133097 @default.
• W2486133097 citedByCount "10" @default.
• W2486133097 countsByYear W24861330972016 @default.
• W2486133097 countsByYear W24861330972017 @default.
• W2486133097 countsByYear W24861330972018 @default.
• W2486133097 countsByYear W24861330972019 @default.
• W2486133097 countsByYear W24861330972020 @default.
• W2486133097 countsByYear W24861330972022 @default.
• W2486133097 countsByYear W24861330972023 @default.
• W2486133097 crossrefType "journal-article" @default.
• W2486133097 hasAuthorship W2486133097A5012247970 @default.
• W2486133097 hasAuthorship W2486133097A5015890126 @default.
• W2486133097 hasAuthorship W2486133097A5068344981 @default.
• W2486133097 hasAuthorship W2486133097A5075305488 @default.
• W2486133097 hasAuthorship W2486133097A5078917080 @default.
• W2486133097 hasAuthorship W2486133097A5086546981 @default.
• W2486133097 hasBestOaLocation W24861330971 @default.
• W2486133097 hasConcept C104317684 @default.
• W2486133097 hasConcept C111919701 @default.
• W2486133097 hasConcept C167625842 @default.
• W2486133097 hasConcept C185592680 @default.

• next