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- W2486144414 abstract "// Hao Hu 1, * , Xi Kun Han 2 , Xiao Ran Long 3, * , Jia Fan 4 , Zhi Ping Yan 1 , Jian Hua Wang 1 , Rong Liu 1 1 Department of Interventional Radiology, Zhongshan Hospital, Shanghai Medical College, Fudan University, Shanghai, China 2 State Key Laboratory of Cardiovascular Disease, Fuwai Hospital, National Center of Cardiovascular Diseases, Chinese Academy of Medical Sciences and Peking Union Medical College, Beijing, China 3 Sun Yat-sen University Cancer Center, Guangzhou, China 4 Liver Cancer Institute, Zhongshan Hospital, Shanghai Medical College, Fudan University, Shanghai, China * These authors have contributed equally to this work Correspondence to: Rong Liu, email: liu.rong@zs-hospital.sh.cn Hao Hu, email: huhaozsyy@126.com Keywords: nomogram, adjuvant transarterial chemoembolization, hepatocellular carcinoma Received: May 16, 2016 Accepted: July 01, 2016 Published: August 05, 2016 ABSTRACT Objective: This study sought to establish an effective and reliable prognostic nomogram to guide the decision for post-surgical adjuvant transarterial chemoembolization (PA-TACE) in patients with hepatitis B virus-related (HBV) hepatocellular carcinoma (HCC). Results: The 1, 3, 5-year overall survival rates were, respectively, 87.7%, 52.1% and 28.3% in the patients from the derivation set and 91.7%, 57.1% and 34.1% in those from the validation set. Five risk factors (HBV-DNA level, platelet count, vascular invasion, change of Child-Pugh score, and tumor diameter) in the multivariate analysis were significantly associated with prognosis. The statistical nomogram incorporated these five factors achieved good calibration and discriminatory abilities with c-index of 0.75 (95% CI 0.67 to 0.83). The findings were supported by the independent external validation set (c-index, 0.69; 95% CI 0.56 to 0.83). Patients who had a nomogram score of less than 180 was considered to have higher survival benefit from PA-TACE. Methods: The nomogram was established based on data obtained from a retrospective study on 235 consecutive patients with HBV HCC who received PA-TACE as an initial therapy from 2006 to 2010 in our center. 84 patients who were collected at another institution between 01/2008 and 12/2010 served as an external validation set. The prognostic nomogram was developed based on the data obtained before the PA-TACE procedure. Predictive accuracy and discriminative ability of the nomogram were assessed by concordance index (C-index), calibration curves, and validation set. Conclusion: The novel nomogram may achieve an optimal prognostic prediction for PA-TACE in HBV-related HCC." @default.
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- W2486144414 date "2016-08-05" @default.
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- W2486144414 title "Prognostic nomogram for post-surgical treatment with adjuvant TACE in hepatitis B virus-related hepatocellular carcinoma" @default.
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- W2486144414 doi "https://doi.org/10.18632/oncotarget.11078" @default.
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