FRINK Linked Data Fragments server

Matches in SemOpenAlex for { <https://semopenalex.org/work/W2486177514> ?p ?o ?g. }

• W2486177514 endingPage "234" @default.
• W2486177514 startingPage "234" @default.
• W2486177514 abstract "Tentoxin, a cyclic tetrapeptide produced by several Alternaria species, inhibits the F₁-ATPase activity of chloroplasts, resulting in chlorosis in sensitive plants. In this study, we report two clustered genes, encoding a putative non-ribosome peptide synthetase (NRPS) TES and a cytochrome P450 protein TES1, that are required for tentoxin biosynthesis in Alternaria alternata strain ZJ33, which was isolated from blighted leaves of Eupatorium adenophorum. Using a pair of primers designed according to the consensus sequences of the adenylation domain of NRPSs, two fragments containing putative adenylation domains were amplified from A. alternata ZJ33, and subsequent PCR analyses demonstrated that these fragments belonged to the same NRPS coding sequence. With no introns, TES consists of a single 15,486 base pair open reading frame encoding a predicted 5161 amino acid protein. Meanwhile, the TES1 gene is predicted to contain five introns and encode a 506 amino acid protein. The TES protein is predicted to be comprised of four peptide synthase modules with two additional N-methylation domains, and the number and arrangement of the modules in TES were consistent with the number and arrangement of the amino acid residues of tentoxin, respectively. Notably, both TES and TES1 null mutants generated via homologous recombination failed to produce tentoxin. This study provides the first evidence concerning the biosynthesis of tentoxin in A. alternata." @default.
• W2486177514 created "2016-08-23" @default.
• W2486177514 creator A5003554535 @default.
• W2486177514 creator A5013962279 @default.
• W2486177514 creator A5046976591 @default.
• W2486177514 creator A5047028153 @default.
• W2486177514 creator A5052615420 @default.
• W2486177514 creator A5054484902 @default.
• W2486177514 date "2016-08-02" @default.
• W2486177514 modified "2023-10-17" @default.
• W2486177514 title "Putative Nonribosomal Peptide Synthetase and Cytochrome P450 Genes Responsible for Tentoxin Biosynthesis in Alternaria alternata ZJ33" @default.
• W2486177514 cites W1964485754 @default.
• W2486177514 cites W1964613976 @default.
• W2486177514 cites W1973999795 @default.
• W2486177514 cites W1981080997 @default.
• W2486177514 cites W1985381418 @default.
• W2486177514 cites W1987446316 @default.
• W2486177514 cites W1990436422 @default.
• W2486177514 cites W2011700260 @default.
• W2486177514 cites W2012190785 @default.
• W2486177514 cites W2018453421 @default.
• W2486177514 cites W2037667706 @default.
• W2486177514 cites W2039418193 @default.
• W2486177514 cites W2044729870 @default.
• W2486177514 cites W2052589072 @default.
• W2486177514 cites W2052986999 @default.
• W2486177514 cites W2053360783 @default.
• W2486177514 cites W2059572826 @default.
• W2486177514 cites W2062356494 @default.
• W2486177514 cites W2081735266 @default.
• W2486177514 cites W2092412789 @default.
• W2486177514 cites W2095079034 @default.
• W2486177514 cites W2114033438 @default.
• W2486177514 cites W2114839447 @default.
• W2486177514 cites W2124254997 @default.
• W2486177514 cites W2131057442 @default.
• W2486177514 cites W2150742287 @default.
• W2486177514 cites W2157262350 @default.
• W2486177514 cites W2181083707 @default.
• W2486177514 cites W4213267564 @default.
• W2486177514 cites W4239071479 @default.
• W2486177514 cites W4239351393 @default.
• W2486177514 doi "https://doi.org/10.3390/toxins8080234" @default.
• W2486177514 hasPubMedCentralId "https://www.ncbi.nlm.nih.gov/pmc/articles/4999850" @default.
• W2486177514 hasPubMedId "https://pubmed.ncbi.nlm.nih.gov/27490569" @default.
• W2486177514 hasPublicationYear "2016" @default.
• W2486177514 type Work @default.
• W2486177514 sameAs 2486177514 @default.
• W2486177514 citedByCount "13" @default.
• W2486177514 countsByYear W24861775142018 @default.
• W2486177514 countsByYear W24861775142020 @default.
• W2486177514 countsByYear W24861775142021 @default.
• W2486177514 countsByYear W24861775142022 @default.
• W2486177514 countsByYear W24861775142023 @default.
• W2486177514 crossrefType "journal-article" @default.
• W2486177514 hasAuthorship W2486177514A5003554535 @default.
• W2486177514 hasAuthorship W2486177514A5013962279 @default.
• W2486177514 hasAuthorship W2486177514A5046976591 @default.
• W2486177514 hasAuthorship W2486177514A5047028153 @default.
• W2486177514 hasAuthorship W2486177514A5052615420 @default.
• W2486177514 hasAuthorship W2486177514A5054484902 @default.
• W2486177514 hasBestOaLocation W24861775141 @default.
• W2486177514 hasConcept C104317684 @default.
• W2486177514 hasConcept C160403918 @default.
• W2486177514 hasConcept C2777379556 @default.
• W2486177514 hasConcept C2780720873 @default.
• W2486177514 hasConcept C515207424 @default.
• W2486177514 hasConcept C54355233 @default.
• W2486177514 hasConcept C553450214 @default.
• W2486177514 hasConcept C55493867 @default.
• W2486177514 hasConcept C59822182 @default.
• W2486177514 hasConcept C86803240 @default.
• W2486177514 hasConceptScore W2486177514C104317684 @default.
• W2486177514 hasConceptScore W2486177514C160403918 @default.
• W2486177514 hasConceptScore W2486177514C2777379556 @default.
• W2486177514 hasConceptScore W2486177514C2780720873 @default.
• W2486177514 hasConceptScore W2486177514C515207424 @default.
• W2486177514 hasConceptScore W2486177514C54355233 @default.
• W2486177514 hasConceptScore W2486177514C553450214 @default.
• W2486177514 hasConceptScore W2486177514C55493867 @default.
• W2486177514 hasConceptScore W2486177514C59822182 @default.
• W2486177514 hasConceptScore W2486177514C86803240 @default.
• W2486177514 hasFunder F4320321001 @default.
• W2486177514 hasFunder F4320322919 @default.
• W2486177514 hasIssue "8" @default.
• W2486177514 hasLocation W24861775141 @default.
• W2486177514 hasLocation W24861775142 @default.
• W2486177514 hasLocation W24861775143 @default.
• W2486177514 hasLocation W24861775144 @default.
• W2486177514 hasOpenAccess W2486177514 @default.
• W2486177514 hasPrimaryLocation W24861775141 @default.
• W2486177514 hasRelatedWork W2007860582 @default.
• W2486177514 hasRelatedWork W2051326459 @default.
• W2486177514 hasRelatedWork W2067058097 @default.
• W2486177514 hasRelatedWork W2074402828 @default.
• W2486177514 hasRelatedWork W2312677772 @default.
• W2486177514 hasRelatedWork W2753890186 @default.
• W2486177514 hasRelatedWork W2904770416 @default.

• next