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• W2486232285 abstract "Abstract Mitochondria are essential organelles involved in energy production, cell signaling, and cell fate. They represent a node for numerous signaling pathways involved both in the processes of cell survival and cell death. Thus, aged and/or dysfunctional mitochondria need to be selectively removed to protect the cells from excessive oxidative stress and cell death. Moreover, the biogenesis of new mitochondria should be compensated by the elimination of the oldest ones. Thus a mitochondrial quality control system is needed for achieving such a task. The selective degradation of mitochondria by autophagy (mitophagy) is a process whereby damaged mitochondria are sequestered into double-membrane vesicles called autophagosomes and transported to lysosomes for degradation. In physiological conditions mitophagy contributes to the maturation of different cellular subsets like red blood cells, the cardiomyocytes adaptation to hypoxia as well as to the selective transmission of the maternal mitochondrial genome (mitochondrial inheritance). Alteration of mitophagy is also associated to pathological situations such as Parkinson’s and Alzheimer’s diseases. Indeed, mutations in the key constituents of the mitophagy’s core machinery have been associated with these neurodegenerative diseases. Hence, understanding the mechanisms of mitophagy regulation and signaling not only would bring a new vision for the comprehension of the physiological adaptation in multicellular organisms but also might help in the development of effective clinical strategies against neurodegenerative diseases. This chapter aims to underline the current advances in the study of mitophagy in physiological and pathological situations." @default.
• W2486232285 created "2016-08-23" @default.
• W2486232285 creator A5024403040 @default.
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• W2486232285 creator A5087574361 @default.
• W2486232285 date "2016-01-01" @default.
• W2486232285 modified "2023-09-23" @default.
• W2486232285 title "Mitophagy" @default.
• W2486232285 cites W1510443235 @default.
• W2486232285 cites W1581105610 @default.
• W2486232285 cites W1877873625 @default.
• W2486232285 cites W1904531393 @default.
• W2486232285 cites W1946989708 @default.
• W2486232285 cites W1964032090 @default.
• W2486232285 cites W1965110900 @default.
• W2486232285 cites W1968432606 @default.
• W2486232285 cites W1968843321 @default.
• W2486232285 cites W1969728632 @default.
• W2486232285 cites W1972336737 @default.
• W2486232285 cites W1973166004 @default.
• W2486232285 cites W1979462186 @default.
• W2486232285 cites W1983724570 @default.
• W2486232285 cites W1989293830 @default.
• W2486232285 cites W1992538476 @default.
• W2486232285 cites W1993733276 @default.
• W2486232285 cites W1997360166 @default.
• W2486232285 cites W2001648286 @default.
• W2486232285 cites W2006696253 @default.
• W2486232285 cites W2007997420 @default.
• W2486232285 cites W2009284075 @default.
• W2486232285 cites W2011124366 @default.
• W2486232285 cites W2014459126 @default.
• W2486232285 cites W2014918593 @default.
• W2486232285 cites W2015905687 @default.
• W2486232285 cites W2018923752 @default.
• W2486232285 cites W2025559428 @default.
• W2486232285 cites W2025872915 @default.
• W2486232285 cites W2026694952 @default.
• W2486232285 cites W2033766052 @default.
• W2486232285 cites W2034087770 @default.
• W2486232285 cites W2034657763 @default.
• W2486232285 cites W2035526886 @default.
• W2486232285 cites W2038028875 @default.
• W2486232285 cites W2043276141 @default.
• W2486232285 cites W2044829505 @default.
• W2486232285 cites W2047242847 @default.
• W2486232285 cites W2047507923 @default.
• W2486232285 cites W2049729563 @default.
• W2486232285 cites W2052889619 @default.
• W2486232285 cites W2055124287 @default.
• W2486232285 cites W2058065156 @default.
• W2486232285 cites W2060480804 @default.
• W2486232285 cites W2060519281 @default.
• W2486232285 cites W2061330513 @default.
• W2486232285 cites W2064127635 @default.
• W2486232285 cites W2064465368 @default.
• W2486232285 cites W2064967819 @default.
• W2486232285 cites W2069519643 @default.
• W2486232285 cites W2072891641 @default.
• W2486232285 cites W2082395741 @default.
• W2486232285 cites W2086557228 @default.
• W2486232285 cites W2091264505 @default.
• W2486232285 cites W2095442327 @default.
• W2486232285 cites W2099926529 @default.
• W2486232285 cites W2100388369 @default.
• W2486232285 cites W2104412320 @default.
• W2486232285 cites W2109773179 @default.
• W2486232285 cites W2119508244 @default.
• W2486232285 cites W2122556106 @default.
• W2486232285 cites W2125868002 @default.
• W2486232285 cites W2127440157 @default.
• W2486232285 cites W2129248872 @default.
• W2486232285 cites W2129750781 @default.
• W2486232285 cites W2130979925 @default.
• W2486232285 cites W2132357771 @default.
• W2486232285 cites W2136388422 @default.
• W2486232285 cites W2138311396 @default.
• W2486232285 cites W2140654974 @default.
• W2486232285 cites W2140679396 @default.
• W2486232285 cites W2144314949 @default.
• W2486232285 cites W2144450295 @default.
• W2486232285 cites W2146122852 @default.
• W2486232285 cites W2147249483 @default.
• W2486232285 cites W2148819754 @default.
• W2486232285 cites W2149090315 @default.
• W2486232285 cites W2155015733 @default.
• W2486232285 cites W2155213268 @default.
• W2486232285 cites W2157334943 @default.
• W2486232285 cites W2158535498 @default.
• W2486232285 cites W2160330769 @default.
• W2486232285 cites W2160697936 @default.
• W2486232285 cites W2160845673 @default.
• W2486232285 cites W2164945122 @default.
• W2486232285 doi "https://doi.org/10.1016/b978-0-12-802936-7.00003-9" @default.
• W2486232285 hasPublicationYear "2016" @default.
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