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• W2486361181 endingPage "e0163302" @default.
• W2486361181 startingPage "e0163302" @default.
• W2486361181 abstract "Trypanosoma cruzi is a protozoan parasite transmitted by a triatomine insect, and causing human Chagas disease in South America. This parasite undergoes a complex life cycle alternating between non-proliferative and dividing forms. Owing to their high energy requirement, replicative epimastigotes of the insect midgut display high endocytic activity. This activity is mainly restricted to the cytostome, by which the cargo is taken up and sorted through the endosomal vesicular network to be delivered to reservosomes, the final lysosomal-like compartments. In African trypanosomes tomato lectin (TL) and ricin, respectively specific to poly-N-acetyllactosamine (poly-LacNAc) and β-D-galactose, allowed the identification of giant chains of poly-LacNAc in N-glycoproteins of the endocytic pathway. We show that in T. cruzi epimastigote forms also, glycoproteins of the endocytic pathway are characterized by the presence of N-linked glycans binding to both ricin and TL. Affinity chromatography using both TL and Griffonia simplicifolia lectin II (GSLII), specific to non-reducing terminal residue of N-acetylglucosamine (GlcNAc), led to an enrichment of glycoproteins of the trypanosomal endocytic pathway. Incubation of live parasites with TL, which selectively bound to the cytostome/cytopharynx, specifically inhibited endocytosis of transferrin (Tf) but not dextran, a marker of fluid endocytosis. Taken together, our data suggest that N-glycan modification of endocytic components plays a crucial role in receptor-mediated endocytosis of T. cruzi." @default.
• W2486361181 created "2016-08-23" @default.
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• W2486361181 date "2016-09-29" @default.
• W2486361181 modified "2023-10-02" @default.
• W2486361181 title "Specific Endocytosis Blockade of Trypanosoma cruzi Exposed to a Poly-LAcNAc Binding Lectin Suggests that Lectin-Sugar Interactions Participate to Receptor-Mediated Endocytosis" @default.
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• W2486361181 doi "https://doi.org/10.1371/journal.pone.0163302" @default.
• W2486361181 hasPubMedCentralId "https://www.ncbi.nlm.nih.gov/pmc/articles/5042520" @default.
• W2486361181 hasPubMedId "https://pubmed.ncbi.nlm.nih.gov/27685262" @default.
• W2486361181 hasPublicationYear "2016" @default.
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