FRINK Linked Data Fragments server

Matches in SemOpenAlex for { <https://semopenalex.org/work/W2486381732> ?p ?o ?g. }

• W2486381732 abstract "Background/Aims: Hypersensitive pain response is often observed in patients with Parkinson's disease (PD); however, the mechanisms responsible for hyperalgesia are not well understood. Chronic neuroinflammation is one of the hallmarks of PD pathophysiology. Since the midbrain periaqueductal gray (PAG) is an important component of the descending inhibitory pathway controlling on central pain transmission, we examined the role for pro-inflammatory cytokines (PICs) system of PAG in regulating exaggerated pain evoked by PD. Methods: We used a rat model of PD to perform the experimental protocols. PD was induced by microinjection of 6-hydroxydopamine to lesion the left medial forebrain bundle. Pain responses to mechanical and thermal stimulation were first examined in control rats and PD rats. Then, ELISA and Western Blot analysis were used to determine PIC levels and their receptors expression. Results: Protein expression of IL-1β, IL-6 and TNF-α receptors (namely, IL-1R, IL-6R and TNFR subtype TNFR1) in the plasma membrane PAG of PD rats was upregulated, whereas the total expression of PIC receptors was not significantly altered. The ratio of membrane protein and total protein (IL-1R, IL-6R and TNFR1) was 1.48±0.15, 1.59±0.18 and 1.67±0.16 in PAG of PD rats (P < 0.05 vs. their respective controls). This was accompanied with increases of PICs of PAG, and decreases of GABA (623±21 ng/mg in control rats and 418±18 ng/mg in PD rats; P < 0.05 vs. control rats) and withdrawal thresholds to mechanical and thermal stimuli. Our data further showed that the concentrations of GABA and withdrawal thresholds were largely restored by blocking those PIC receptors in PAG of PD rats. Stimulation of GABA receptors in PAG of PD rats also blunted a decrease in withdrawal thresholds. Conclusions: Our data suggest that upregulation of the membrane PIC receptor in the PAG of PD rats is likely to impair the descending inhibitory pathways in regulating pain transmission and thereby plays a role in the development of hypersensitive pain response in PD." @default.
• W2486381732 created "2016-08-23" @default.
• W2486381732 creator A5005184723 @default.
• W2486381732 creator A5011622976 @default.
• W2486381732 creator A5021550676 @default.
• W2486381732 creator A5046709081 @default.
• W2486381732 creator A5049377474 @default.
• W2486381732 creator A5055649072 @default.
• W2486381732 creator A5089888126 @default.
• W2486381732 date "2016-07-25" @default.
• W2486381732 modified "2023-10-14" @default.
• W2486381732 title "Contribution of Pro-inflammatory Cytokine Signaling within Midbrain Periaqueductal Gray to Pain Sensitivity in Parkinson’s Disease via GABAergic Pathway" @default.
• W2486381732 cites W1496850081 @default.
• W2486381732 cites W1516995431 @default.
• W2486381732 cites W1565148871 @default.
• W2486381732 cites W1776476655 @default.
• W2486381732 cites W1964917696 @default.
• W2486381732 cites W1965453486 @default.
• W2486381732 cites W1965942744 @default.
• W2486381732 cites W1970433486 @default.
• W2486381732 cites W1974924674 @default.
• W2486381732 cites W1977265431 @default.
• W2486381732 cites W1980020952 @default.
• W2486381732 cites W1983781894 @default.
• W2486381732 cites W1993123165 @default.
• W2486381732 cites W1996548067 @default.
• W2486381732 cites W2002289659 @default.
• W2486381732 cites W2007635429 @default.
• W2486381732 cites W2012811416 @default.
• W2486381732 cites W2013885507 @default.
• W2486381732 cites W2014182955 @default.
• W2486381732 cites W2017287105 @default.
• W2486381732 cites W2021043915 @default.
• W2486381732 cites W2021163482 @default.
• W2486381732 cites W2021194790 @default.
• W2486381732 cites W2021602283 @default.
• W2486381732 cites W2030204659 @default.
• W2486381732 cites W2030857678 @default.
• W2486381732 cites W2036764555 @default.
• W2486381732 cites W2037043198 @default.
• W2486381732 cites W2047817815 @default.
• W2486381732 cites W2062700118 @default.
• W2486381732 cites W2066106589 @default.
• W2486381732 cites W2069414159 @default.
• W2486381732 cites W2069681479 @default.
• W2486381732 cites W2074997282 @default.
• W2486381732 cites W2081090537 @default.
• W2486381732 cites W2087356150 @default.
• W2486381732 cites W2089100446 @default.
• W2486381732 cites W2090894311 @default.
• W2486381732 cites W2095718867 @default.
• W2486381732 cites W2101243397 @default.
• W2486381732 cites W2121109193 @default.
• W2486381732 cites W2133712961 @default.
• W2486381732 cites W2138192231 @default.
• W2486381732 cites W2161325655 @default.
• W2486381732 cites W2161934021 @default.
• W2486381732 cites W2162001557 @default.
• W2486381732 cites W2172201406 @default.
• W2486381732 cites W2279354379 @default.
• W2486381732 cites W3021212401 @default.
• W2486381732 cites W4211151576 @default.
• W2486381732 cites W973831090 @default.
• W2486381732 doi "https://doi.org/10.3389/fneur.2016.00104" @default.
• W2486381732 hasPubMedCentralId "https://www.ncbi.nlm.nih.gov/pmc/articles/4959028" @default.
• W2486381732 hasPubMedId "https://pubmed.ncbi.nlm.nih.gov/27504103" @default.
• W2486381732 hasPublicationYear "2016" @default.
• W2486381732 type Work @default.
• W2486381732 sameAs 2486381732 @default.
• W2486381732 citedByCount "9" @default.
• W2486381732 countsByYear W24863817322017 @default.
• W2486381732 countsByYear W24863817322018 @default.
• W2486381732 countsByYear W24863817322020 @default.
• W2486381732 countsByYear W24863817322021 @default.
• W2486381732 countsByYear W24863817322022 @default.
• W2486381732 countsByYear W24863817322023 @default.
• W2486381732 crossrefType "journal-article" @default.
• W2486381732 hasAuthorship W2486381732A5005184723 @default.
• W2486381732 hasAuthorship W2486381732A5011622976 @default.
• W2486381732 hasAuthorship W2486381732A5021550676 @default.
• W2486381732 hasAuthorship W2486381732A5046709081 @default.
• W2486381732 hasAuthorship W2486381732A5049377474 @default.
• W2486381732 hasAuthorship W2486381732A5055649072 @default.
• W2486381732 hasAuthorship W2486381732A5089888126 @default.
• W2486381732 hasBestOaLocation W24863817321 @default.
• W2486381732 hasConcept C126322002 @default.
• W2486381732 hasConcept C134018914 @default.
• W2486381732 hasConcept C137183658 @default.
• W2486381732 hasConcept C169760540 @default.
• W2486381732 hasConcept C170493617 @default.
• W2486381732 hasConcept C185592680 @default.
• W2486381732 hasConcept C2776669363 @default.
• W2486381732 hasConcept C2776914184 @default.
• W2486381732 hasConcept C2779177108 @default.
• W2486381732 hasConcept C2781069035 @default.
• W2486381732 hasConcept C513476851 @default.
• W2486381732 hasConcept C529278444 @default.
• W2486381732 hasConcept C552161191 @default.
• W2486381732 hasConcept C62525196 @default.
• W2486381732 hasConcept C71924100 @default.

• next