Matches in SemOpenAlex for { <https://semopenalex.org/work/W2486707310> ?p ?o ?g. }
Showing items 1 to 91 of
91
with 100 items per page.
- W2486707310 abstract "Objective The heterogeneous human frontal pole has been identified as a node in the dysfunctional network of major depressive disorder (MDD) ( Mayberg, 2003 ). The contribution of the medial (socio affective) versus lateral (cognitive) frontal pole to major depression pathogenesis is currently unclear. The authors performed morphometric comparison of the microstructurally informed subdivisions of human frontal pole ( Bludau et al., 2014 ) between depressed patients and comparison subjects using both uni- and multivariate statistics. Method Multisite voxel- and region-based morphometric MRI analysis was conducted in 73 depressed patients and 73 matched comparison subjects without psychiatric history (Gender: Controls [f/m]40/33; Patients [f/m]40/33; chi 2 :1.0, Age: Controls [mean/ SD]38.51/12.56; Patients [mean/SD]41.70/12.95; ttest (p-value): 0.13). Frontal pole volume was first compared between depressed patients and comparison subjects by subdivision-wise classical morphometric analysis. In a second approach, frontal pole volume was compared by subdivision-naive multivariate searchlight analysis based on support vector machines. Results The group comparison showed a significant decrease in volume of the left medial part of the frontal pole (left Fp2) of MDD patients compared to the controls ( Fig. 1 ) ( p r = −0.32)) and within the patients of all sites (Fp2_L ∼ BDI ( r = −0.26)). Duration as well as episodes also correlates negatively with the volume of left Fp2 within the patients (Fp2_L ∼ duration ( r = −0.35); Fp2_L ∼ episodes ( r = −0.34)). Histologically uninformed multivariate voxel-wise statistics provided converging evidence for structural aberrations specific to the microstructurally defined medial area of the frontal pole in depressed patients ( Fig. 2 ). Conclusions Across disparate methods, subregion specificity in the left medial frontal pole volume in depressed patients was demonstrated. Indeed, the frontal pole was shown to structurally and functionally connect to other key regions in major depression pathology, such as the anterior cingulate cortex and the amygdala via the uncinate fasciculus. Present and previous findings consolidate the left medial portion of the frontal pole as particularly altered in major depression." @default.
- W2486707310 created "2016-08-23" @default.
- W2486707310 creator A5002412087 @default.
- W2486707310 creator A5003889607 @default.
- W2486707310 creator A5007313280 @default.
- W2486707310 creator A5009333521 @default.
- W2486707310 creator A5026460417 @default.
- W2486707310 creator A5031402912 @default.
- W2486707310 creator A5051587217 @default.
- W2486707310 creator A5069643316 @default.
- W2486707310 creator A5073016053 @default.
- W2486707310 creator A5073171809 @default.
- W2486707310 creator A5089869374 @default.
- W2486707310 date "2016-09-01" @default.
- W2486707310 modified "2023-09-24" @default.
- W2486707310 title "EP 81. Medial prefrontal aberrations in major depressive disorder revealed by Cytoarchitectonically informed Voxel-based Morphometry" @default.
- W2486707310 cites W2022843626 @default.
- W2486707310 cites W2147969224 @default.
- W2486707310 doi "https://doi.org/10.1016/j.clinph.2016.05.130" @default.
- W2486707310 hasPublicationYear "2016" @default.
- W2486707310 type Work @default.
- W2486707310 sameAs 2486707310 @default.
- W2486707310 citedByCount "1" @default.
- W2486707310 countsByYear W24867073102018 @default.
- W2486707310 crossrefType "journal-article" @default.
- W2486707310 hasAuthorship W2486707310A5002412087 @default.
- W2486707310 hasAuthorship W2486707310A5003889607 @default.
- W2486707310 hasAuthorship W2486707310A5007313280 @default.
- W2486707310 hasAuthorship W2486707310A5009333521 @default.
- W2486707310 hasAuthorship W2486707310A5026460417 @default.
- W2486707310 hasAuthorship W2486707310A5031402912 @default.
- W2486707310 hasAuthorship W2486707310A5051587217 @default.
- W2486707310 hasAuthorship W2486707310A5069643316 @default.
- W2486707310 hasAuthorship W2486707310A5073016053 @default.
- W2486707310 hasAuthorship W2486707310A5073171809 @default.
- W2486707310 hasAuthorship W2486707310A5089869374 @default.
- W2486707310 hasConcept C118552586 @default.
- W2486707310 hasConcept C126322002 @default.
- W2486707310 hasConcept C126838900 @default.
- W2486707310 hasConcept C139719470 @default.
- W2486707310 hasConcept C15744967 @default.
- W2486707310 hasConcept C162324750 @default.
- W2486707310 hasConcept C169900460 @default.
- W2486707310 hasConcept C27502469 @default.
- W2486707310 hasConcept C2776867660 @default.
- W2486707310 hasConcept C2780051608 @default.
- W2486707310 hasConcept C38180746 @default.
- W2486707310 hasConcept C54170458 @default.
- W2486707310 hasConcept C548259974 @default.
- W2486707310 hasConcept C71924100 @default.
- W2486707310 hasConceptScore W2486707310C118552586 @default.
- W2486707310 hasConceptScore W2486707310C126322002 @default.
- W2486707310 hasConceptScore W2486707310C126838900 @default.
- W2486707310 hasConceptScore W2486707310C139719470 @default.
- W2486707310 hasConceptScore W2486707310C15744967 @default.
- W2486707310 hasConceptScore W2486707310C162324750 @default.
- W2486707310 hasConceptScore W2486707310C169900460 @default.
- W2486707310 hasConceptScore W2486707310C27502469 @default.
- W2486707310 hasConceptScore W2486707310C2776867660 @default.
- W2486707310 hasConceptScore W2486707310C2780051608 @default.
- W2486707310 hasConceptScore W2486707310C38180746 @default.
- W2486707310 hasConceptScore W2486707310C54170458 @default.
- W2486707310 hasConceptScore W2486707310C548259974 @default.
- W2486707310 hasConceptScore W2486707310C71924100 @default.
- W2486707310 hasLocation W24867073101 @default.
- W2486707310 hasOpenAccess W2486707310 @default.
- W2486707310 hasPrimaryLocation W24867073101 @default.
- W2486707310 hasRelatedWork W1823920491 @default.
- W2486707310 hasRelatedWork W1995665686 @default.
- W2486707310 hasRelatedWork W2042669998 @default.
- W2486707310 hasRelatedWork W2050536595 @default.
- W2486707310 hasRelatedWork W2057998596 @default.
- W2486707310 hasRelatedWork W2088065171 @default.
- W2486707310 hasRelatedWork W2175558603 @default.
- W2486707310 hasRelatedWork W2360813193 @default.
- W2486707310 hasRelatedWork W2361006058 @default.
- W2486707310 hasRelatedWork W2362485738 @default.
- W2486707310 hasRelatedWork W2385721253 @default.
- W2486707310 hasRelatedWork W2386877200 @default.
- W2486707310 hasRelatedWork W2390987023 @default.
- W2486707310 hasRelatedWork W2803277235 @default.
- W2486707310 hasRelatedWork W2954308429 @default.
- W2486707310 hasRelatedWork W3029029996 @default.
- W2486707310 hasRelatedWork W3032212287 @default.
- W2486707310 hasRelatedWork W3032296261 @default.
- W2486707310 hasRelatedWork W3128727056 @default.
- W2486707310 hasRelatedWork W3184355718 @default.
- W2486707310 isParatext "false" @default.
- W2486707310 isRetracted "false" @default.
- W2486707310 magId "2486707310" @default.
- W2486707310 workType "article" @default.