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- W2486772016 abstract "Ionizing radiation is one of very few exogenous exposures are known to increase breast cancer risk. Both human and experimental animal data suggest that there are additional poorly understood factors associated with aging or other life events that are permissive of, or actively promote, carcinogenesis. For example, Land et al. conducted a nested case-control study (Land et al., 1994) in which sophisticated statistical modeling indicated that early first birth, multiple births and long cumulative lactation history protect not only against breast cancer per se, but against radiation-induced breast cancer in this population. Thus, while radiation exposure increases breast cancer risk, these events are unlikely to be sufficient as evidenced by the long latency (approximately 40 years) between exposure and disease, and the observation that subsequent tissue and reproductive processes can modify risk. A more mechanistic understanding of the cellular and molecular events that occur over a woman’s lifetime is necessary to understand the increased risk of breast cancer in populations exposed during puberty." @default.
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- W2486772016 date "2006-01-01" @default.
- W2486772016 modified "2023-09-27" @default.
- W2486772016 title "Mechanisms and Actions of Ionizing Radiation as a Breast Carcinogen" @default.
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