Matches in SemOpenAlex for { <https://semopenalex.org/work/W2486832766> ?p ?o ?g. }
- W2486832766 endingPage "2926" @default.
- W2486832766 startingPage "2915" @default.
- W2486832766 abstract "Neoplastic cells metabolize higher amounts of glucose relative to normal cells in order to cover increased energetic and anabolic needs. Inhibition of the glycolytic enzyme 6-phosphofructo-2-kinase/fructose-2,6-bisphosphatase 3 (PFKFB3) diminishes cancer cell proliferation and tumour growth in animals. In this work, we investigate the crosstalk between PFKFB3 and TIGAR (TP53-Induced Glycolysis and Apoptosis Regulator), a protein known to protect cells from oxidative stress. Our results show consistent TIGAR induction in HeLa cells in response to PFKFB3 knockdown. Upon PFKFB3 silencing, cells undergo oxidative stress and trigger Akt phosphorylation. This leads to induction of a TIGAR-mediated prosurvival pathway that reduces both oxidative stress and cell death. As TIGAR is known to have a role in DNA repair, it could serve as a potential target for the development of effective antineoplastic therapies." @default.
- W2486832766 created "2016-08-23" @default.
- W2486832766 creator A5001890941 @default.
- W2486832766 creator A5004978130 @default.
- W2486832766 creator A5022041368 @default.
- W2486832766 creator A5049427687 @default.
- W2486832766 creator A5063956593 @default.
- W2486832766 creator A5068166024 @default.
- W2486832766 creator A5075076955 @default.
- W2486832766 date "2016-08-24" @default.
- W2486832766 modified "2023-10-18" @default.
- W2486832766 title "Akt mediates TIGAR induction in HeLa cells following PFKFB3 inhibition" @default.
- W2486832766 cites W1599277235 @default.
- W2486832766 cites W1691578538 @default.
- W2486832766 cites W1964725493 @default.
- W2486832766 cites W1966761605 @default.
- W2486832766 cites W1978774712 @default.
- W2486832766 cites W1982174124 @default.
- W2486832766 cites W1984543978 @default.
- W2486832766 cites W1990253071 @default.
- W2486832766 cites W1995892822 @default.
- W2486832766 cites W2000081372 @default.
- W2486832766 cites W2011034468 @default.
- W2486832766 cites W2011241671 @default.
- W2486832766 cites W2013747211 @default.
- W2486832766 cites W2014960027 @default.
- W2486832766 cites W2028558866 @default.
- W2486832766 cites W2040031230 @default.
- W2486832766 cites W2051502501 @default.
- W2486832766 cites W2055160013 @default.
- W2486832766 cites W2055644950 @default.
- W2486832766 cites W2057559671 @default.
- W2486832766 cites W2069076935 @default.
- W2486832766 cites W2072451938 @default.
- W2486832766 cites W2077367078 @default.
- W2486832766 cites W2077669333 @default.
- W2486832766 cites W2081899669 @default.
- W2486832766 cites W2087468878 @default.
- W2486832766 cites W2089352562 @default.
- W2486832766 cites W2105685115 @default.
- W2486832766 cites W2117840705 @default.
- W2486832766 cites W2119239003 @default.
- W2486832766 cites W2122157702 @default.
- W2486832766 cites W2138590199 @default.
- W2486832766 cites W2163981813 @default.
- W2486832766 cites W2167797756 @default.
- W2486832766 cites W2171112998 @default.
- W2486832766 cites W2197912162 @default.
- W2486832766 cites W2233026563 @default.
- W2486832766 cites W2322803810 @default.
- W2486832766 doi "https://doi.org/10.1002/1873-3468.12338" @default.
- W2486832766 hasPubMedId "https://pubmed.ncbi.nlm.nih.gov/27491040" @default.
- W2486832766 hasPublicationYear "2016" @default.
- W2486832766 type Work @default.
- W2486832766 sameAs 2486832766 @default.
- W2486832766 citedByCount "16" @default.
- W2486832766 countsByYear W24868327662016 @default.
- W2486832766 countsByYear W24868327662017 @default.
- W2486832766 countsByYear W24868327662018 @default.
- W2486832766 countsByYear W24868327662021 @default.
- W2486832766 countsByYear W24868327662022 @default.
- W2486832766 crossrefType "journal-article" @default.
- W2486832766 hasAuthorship W2486832766A5001890941 @default.
- W2486832766 hasAuthorship W2486832766A5004978130 @default.
- W2486832766 hasAuthorship W2486832766A5022041368 @default.
- W2486832766 hasAuthorship W2486832766A5049427687 @default.
- W2486832766 hasAuthorship W2486832766A5063956593 @default.
- W2486832766 hasAuthorship W2486832766A5068166024 @default.
- W2486832766 hasAuthorship W2486832766A5075076955 @default.
- W2486832766 hasBestOaLocation W24868327661 @default.
- W2486832766 hasConcept C104317684 @default.
- W2486832766 hasConcept C119056186 @default.
- W2486832766 hasConcept C121608353 @default.
- W2486832766 hasConcept C1491633281 @default.
- W2486832766 hasConcept C173396325 @default.
- W2486832766 hasConcept C181199279 @default.
- W2486832766 hasConcept C185592680 @default.
- W2486832766 hasConcept C190283241 @default.
- W2486832766 hasConcept C20251656 @default.
- W2486832766 hasConcept C2776151105 @default.
- W2486832766 hasConcept C2777366897 @default.
- W2486832766 hasConcept C31573885 @default.
- W2486832766 hasConcept C502942594 @default.
- W2486832766 hasConcept C54355233 @default.
- W2486832766 hasConcept C55493867 @default.
- W2486832766 hasConcept C57600042 @default.
- W2486832766 hasConcept C62112901 @default.
- W2486832766 hasConcept C62478195 @default.
- W2486832766 hasConcept C75217442 @default.
- W2486832766 hasConcept C86803240 @default.
- W2486832766 hasConcept C95444343 @default.
- W2486832766 hasConcept C96232424 @default.
- W2486832766 hasConceptScore W2486832766C104317684 @default.
- W2486832766 hasConceptScore W2486832766C119056186 @default.
- W2486832766 hasConceptScore W2486832766C121608353 @default.
- W2486832766 hasConceptScore W2486832766C1491633281 @default.
- W2486832766 hasConceptScore W2486832766C173396325 @default.
- W2486832766 hasConceptScore W2486832766C181199279 @default.