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- W2486937209 abstract "This chapter discusses the biochemical and the functional aspects of two inhibitory signals, stimulated by the cellular ligands programmed death ligand 1 (PDL-1) and galectin 1—that help create an immunosuppressive network in the tumor microenvironment. These inhibitory signals can influence the tumor progression by modulating the activation, differentiation, and survival of the effector T cells. The programmed death 1 (PD-1) is a 55-kd member of the Ig superfamily. The activity of PD-1 on the peripheral lymphocytes is most critical for regulating the immune responses. The PD-1 surface expression is minimally detected on the naive T- and B- cells. However, it is inducibly expressed on both the lymphocyte populations following activation, implying that the activated T and B cells are the main cellular targets for PD-1 signaling. PD-L2/B7-DC are shown to be costimulatory rather than inhibitory in certain model systems in vivo . Transfection of tumor cells to express the PD-L2 led to the improved recognition in vitro and superior tumor rejection in vivo." @default.
- W2486937209 created "2016-08-23" @default.
- W2486937209 creator A5024226262 @default.
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- W2486937209 date "2007-01-01" @default.
- W2486937209 modified "2023-10-07" @default.
- W2486937209 title "Programmed Death Ligand-1 and Galectin-1: Pieces in the Puzzle of Tumor-Immune Escape" @default.
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- W2486937209 doi "https://doi.org/10.1016/b978-012372551-6/50082-1" @default.
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