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- W248714897 abstract "This chapter discusses the steroid receptors in the lymphoid organs of the chick. Two to three week old chickens were injected with various doses of dexamethasone phosphate or triamcinolone acetonide 48 and 24 hour before the experiment. It is shown that glucocorticoids caused a dose-dependent decrease in the weight and in thymidine kinase (TK) activity of lymphoid tissues. The three different organs did not respond in the same extent to hormone treatment. The most pronounced effect was observed on the thymus, somewhat less on the spleen while the bursa of Fabricius was rather resistant to glucocorticoid treatment. It is found that TK activity in the bursa even increased significantly after very small doses of steroid were given. The different lymphoid cell populations showed different sensitivity to glucocorticoids both in vivo and in vitro . The thymus was the most sensitive and the bursa Fabricius the most resistant to glucocorticoid treatment. Responsiveness to glucocorticoids of these lymphocytes does not seem to correlate with their glucocorticoid receptor content or the binding affinity of the receptors. The gluco-receptors from all tissues examined showed similar specificity for steroids." @default.
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- W248714897 date "1981-01-01" @default.
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- W248714897 title "STEROID RECEPTORS IN THE LYMPHOID ORGANS OF THE CHICK" @default.
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- W248714897 doi "https://doi.org/10.1016/b978-0-08-027355-6.50051-0" @default.
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