FRINK Linked Data Fragments server

Matches in SemOpenAlex for { <https://semopenalex.org/work/W2487160194> ?p ?o ?g. }

• W2487160194 endingPage "384" @default.
• W2487160194 startingPage "377" @default.
• W2487160194 abstract "Hypoxic hepatitis is a clinical condition precipitated by prolonged periods of oxygen deprivation to the liver. It can have several underlying causes. Despite its prevalence in critically ill patients, which can reach upwards of 10%, very little is known about the mechanisms of injury. Thus, we set out to measure previously identified circulating biomarkers in an attempt to describe mechanisms of injury following hypoxic hepatitis.Plasma from patients diagnosed with hypoxic hepatitis was collected for this study. Biomarkers of hepatocellular injury, mitochondrial damage and cell death were measured. These results were compared against results obtained from well-characterized acetaminophen overdose patients.At peak injury, ALT measured 4082±606 U/L and gradually decreased over 5 days, corresponding to the clinically observed pattern of hypoxic hepatitis. Levels of GDH showed a similar pattern, but neither ALT nor GDH were significantly higher in these patients than in acetaminophen patients. Plasma levels of DNA fragments mimicked hepatocellular injury as measured by ALT and miRNA-122. Interestingly, we found a significant increase in caspase-cleaved cytokeratin-18; however, the full-length form greatly exceeded the cleaved form at the time of maximum injury (45837±12085 vs 2528±1074 U/L). We also found an increase in acHMGB1 at later time points indicating a possible role of inflammation, but cytokine levels at these times were actually decreased relative to early time points.The mechanism of injury following hypoxic hepatitis involves mitochondrial damage and DNA fragmentation. Importantly, necrosis, rather than apoptosis, is the main mode of cell death." @default.
• W2487160194 created "2016-08-23" @default.
• W2487160194 creator A5001390441 @default.
• W2487160194 creator A5007377260 @default.
• W2487160194 creator A5031360889 @default.
• W2487160194 creator A5043335943 @default.
• W2487160194 creator A5046626990 @default.
• W2487160194 creator A5048846344 @default.
• W2487160194 creator A5060242274 @default.
• W2487160194 creator A5064483920 @default.
• W2487160194 creator A5087156903 @default.
• W2487160194 date "2016-08-06" @default.
• W2487160194 modified "2023-10-15" @default.
• W2487160194 title "Plasma biomarkers to study mechanisms of liver injury in patients with hypoxic hepatitis" @default.
• W2487160194 cites W1496557670 @default.
• W2487160194 cites W1568357466 @default.
• W2487160194 cites W1600576641 @default.
• W2487160194 cites W1614484620 @default.
• W2487160194 cites W18540568 @default.
• W2487160194 cites W1968156832 @default.
• W2487160194 cites W1970553359 @default.
• W2487160194 cites W1972308512 @default.
• W2487160194 cites W1990769348 @default.
• W2487160194 cites W1998609605 @default.
• W2487160194 cites W2011471632 @default.
• W2487160194 cites W2013278578 @default.
• W2487160194 cites W2015705899 @default.
• W2487160194 cites W2021032684 @default.
• W2487160194 cites W2029068688 @default.
• W2487160194 cites W2029456365 @default.
• W2487160194 cites W2030771740 @default.
• W2487160194 cites W2041439564 @default.
• W2487160194 cites W2053438154 @default.
• W2487160194 cites W2070753131 @default.
• W2487160194 cites W2074545478 @default.
• W2487160194 cites W2079118329 @default.
• W2487160194 cites W2086714780 @default.
• W2487160194 cites W2102834219 @default.
• W2487160194 cites W2111395199 @default.
• W2487160194 cites W2111848990 @default.
• W2487160194 cites W2117807235 @default.
• W2487160194 cites W2126790202 @default.
• W2487160194 cites W2136956219 @default.
• W2487160194 cites W2143053936 @default.
• W2487160194 cites W2158501840 @default.
• W2487160194 cites W2167322494 @default.
• W2487160194 cites W2171501507 @default.
• W2487160194 cites W2326668058 @default.
• W2487160194 doi "https://doi.org/10.1111/liv.13202" @default.
• W2487160194 hasPubMedCentralId "https://www.ncbi.nlm.nih.gov/pmc/articles/5243938" @default.
• W2487160194 hasPubMedId "https://pubmed.ncbi.nlm.nih.gov/27429052" @default.
• W2487160194 hasPublicationYear "2016" @default.
• W2487160194 type Work @default.
• W2487160194 sameAs 2487160194 @default.
• W2487160194 citedByCount "38" @default.
• W2487160194 countsByYear W24871601942016 @default.
• W2487160194 countsByYear W24871601942017 @default.
• W2487160194 countsByYear W24871601942018 @default.
• W2487160194 countsByYear W24871601942019 @default.
• W2487160194 countsByYear W24871601942020 @default.
• W2487160194 countsByYear W24871601942021 @default.
• W2487160194 countsByYear W24871601942022 @default.
• W2487160194 countsByYear W24871601942023 @default.
• W2487160194 crossrefType "journal-article" @default.
• W2487160194 hasAuthorship W2487160194A5001390441 @default.
• W2487160194 hasAuthorship W2487160194A5007377260 @default.
• W2487160194 hasAuthorship W2487160194A5031360889 @default.
• W2487160194 hasAuthorship W2487160194A5043335943 @default.
• W2487160194 hasAuthorship W2487160194A5046626990 @default.
• W2487160194 hasAuthorship W2487160194A5048846344 @default.
• W2487160194 hasAuthorship W2487160194A5060242274 @default.
• W2487160194 hasAuthorship W2487160194A5064483920 @default.
• W2487160194 hasAuthorship W2487160194A5087156903 @default.
• W2487160194 hasBestOaLocation W24871601942 @default.
• W2487160194 hasConcept C126322002 @default.
• W2487160194 hasConcept C142724271 @default.
• W2487160194 hasConcept C178790620 @default.
• W2487160194 hasConcept C185592680 @default.
• W2487160194 hasConcept C190283241 @default.
• W2487160194 hasConcept C203014093 @default.
• W2487160194 hasConcept C2776029263 @default.
• W2487160194 hasConcept C2776637226 @default.
• W2487160194 hasConcept C2778593092 @default.
• W2487160194 hasConcept C2778722691 @default.
• W2487160194 hasConcept C31573885 @default.
• W2487160194 hasConcept C43759708 @default.
• W2487160194 hasConcept C503630168 @default.
• W2487160194 hasConcept C540031477 @default.
• W2487160194 hasConcept C55493867 @default.
• W2487160194 hasConcept C71924100 @default.
• W2487160194 hasConcept C7836513 @default.
• W2487160194 hasConcept C86803240 @default.
• W2487160194 hasConcept C90924648 @default.
• W2487160194 hasConcept C98274493 @default.
• W2487160194 hasConceptScore W2487160194C126322002 @default.
• W2487160194 hasConceptScore W2487160194C142724271 @default.
• W2487160194 hasConceptScore W2487160194C178790620 @default.
• W2487160194 hasConceptScore W2487160194C185592680 @default.

• next