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- W2487169079 abstract "Cephalothin (also spelled cefalothin and cefalotin) and cefazolin (also spelled cephazolin) are semisynthetic cephalosporins derived from cephalosporin C, a natural antibiotic produced by a strain of the fungus Acremonium chrysogenum (previously known as Cephalosporium acremonium) (Griffith and Black, 1964). The cephalosporin C nucleus, 7-ACA, is closely related but not identical to the penicillin nucleus, 6-APA. Although very similar compounds (Wick and Preston, 1972), cefazolin was introduced after cephalothin with the practical advantage of maintaining higher serum concentrations because of its longer half-life. Both cephalothin and cefazolin are described as first-generation cephalosporins." @default.
- W2487169079 created "2016-08-23" @default.
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- W2487169079 date "2017-01-01" @default.
- W2487169079 modified "2023-09-27" @default.
- W2487169079 title "Cephalothin and cefazolin" @default.
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