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• W2487198596 abstract "The aim of this study was to improve the transdermal delivery of cyclobenzaprine (CBZ) from drug-in-adhesive patch which showed less side effects and better compliance. CBZ base was prepared and then characterized using differential scanning calorimetry (DSC). The interaction between CBZ and pressure-sensitive adhesive (PSA) was determined by Fourier Transform Infrared Spectroscopy (FT-IR). The influences of PSAs, penetration enhancers, patch thickness and drug content on the transdermal delivery of CBZ were studied thoroughly in vitro. Both CBZ releasing from patch and penetrating through the skin showed very great effect on the transdermal delivery of CBZ. The percentage of drug released from patch was increased with the decreasing of patch thickness, and so did the permeation percentage. The stratum corneum (SC) contributed approximately 57% resistance of total skin permeation resistance, and Span 20 increased the transdermal permeation by approximately 1.59-fold. The pharmacokinetic parameters were obtained through in vivo experiments of the optimized formulation using rabbit. Furthermore, the in vitro skin permeation results of CBZ patch correlated well with the in vivo absorption results in rabbit." @default.
• W2487198596 created "2016-08-23" @default.
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• W2487198596 date "2016-07-19" @default.
• W2487198596 modified "2023-09-24" @default.
• W2487198596 title "Two steps modification for improvement of cyclobenzaprine transdermal delivery: releasing from patch and penetrating through skin" @default.
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• W2487198596 doi "https://doi.org/10.1080/03639045.2016.1195402" @default.
• W2487198596 hasPubMedId "https://pubmed.ncbi.nlm.nih.gov/27436573" @default.
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