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- W2487309908 abstract "The influence of chain length and side-chain modifications of ACTH-derived peptides on active avoidance behaviour in rats will be discussed. H-Met(O2)-Glu-His--Phe-D-Lys-Phe-OH (Org 2766) emerged from these studies as an orally active peptide with an increased potency and selectivity of action. Physico-chemical data (from the literature) on the reference peptide ACTH--(4-10) did not point to a preferred conformation in solution, whereas in the crystalline state an antiparallel β-pleated sheet structure was found. At the receptor site we suggested an α-helical conformation in which the Phe and Met residues are close together. Additional support for this suggestion came from the behavioural activity of [des-Tyr1, Met5]enkephalin and of cyclo--(-Phe-Met-εAhx-), εAhx merely serving as a spacer." @default.
- W2487309908 created "2016-08-23" @default.
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- W2487309908 date "1984-04-24" @default.
- W2487309908 modified "2023-09-24" @default.
- W2487309908 title "Structure-Behavioral Activity Relationships of Peptides Derived from ACTH" @default.
- W2487309908 doi "https://doi.org/10.1021/bk-1984-0251.ch007" @default.
- W2487309908 hasPublicationYear "1984" @default.
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