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- W2487334352 abstract "Anesthetic emergencies such as prolonged apnea following administration of succinylcholine, malignant hyperthermia following exposure to volatile anaesthetics, and life-threatening acute porphyria after thiopentone use have catalyzed pharmacogenetic evolution since the early 1950s. In current anesthetic practice, there is wide interindividual variability in drug response, partly explained by genetic variation in drug-metabolizing enzymes or drug targets. The ultimate goal of pharmacogenomics research is to understand the molecular basis that underlies variability in drug metabolism, efficacy, and side effects, in order to tailor therapy and minimize risk. This chapter addresses the basic principles of pharmacogenomics and their application to drugs used in anaesthetic practice." @default.
- W2487334352 created "2016-08-23" @default.
- W2487334352 creator A5005291203 @default.
- W2487334352 creator A5083805156 @default.
- W2487334352 date "2014-01-01" @default.
- W2487334352 modified "2023-09-28" @default.
- W2487334352 title "Pharmacogenomics in Anesthesia" @default.
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