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- W2487346095 endingPage "1016" @default.
- W2487346095 startingPage "991" @default.
- W2487346095 abstract "Polyglutamine (polyQ) hereditary ataxias comprise six disorders, including spinocerebellar ataxia type 1, type 2, Machado–Joseph disease, type 6, type 7, type 17, and dentatorubral-pallidoluysian atrophy. PolyQ ataxias are all neurological disorders, and their pathology is mainly related to dysfunction or loss of neurons in the central nervous system. The mechanisms of the disease are not fully understood and may include a gain and/or loss of function in the mutant protein, which becomes toxic to cells. Transgenic mouse models are very powerful tools for exploring polyQ ataxias. These models are created to study the following two aspects: the disease process and potential therapies for hereditary ataxias that are currently incurable. Therefore, in this chapter, we review the variety of mouse models of polyQ ataxias and discuss the aspects of ataxia pathogenesis that have been discovered via mouse models of particular diseases. Moreover, we review studies that test the feasibility of particular therapeutic strategies in mouse models of polyQ ataxia. This chapter complements our other reviews and databases and has been intensively updated with new models and therapeutic approaches." @default.
- W2487346095 created "2016-08-23" @default.
- W2487346095 creator A5007655910 @default.
- W2487346095 creator A5016819260 @default.
- W2487346095 creator A5039950251 @default.
- W2487346095 creator A5055129588 @default.
- W2487346095 date "2015-01-01" @default.
- W2487346095 modified "2023-09-26" @default.
- W2487346095 title "Mouse Models of SCA3 and Other Polyglutamine Repeat Ataxias" @default.
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