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- W2487419409 endingPage "974" @default.
- W2487419409 startingPage "961" @default.
- W2487419409 abstract "Introduction: Primary HPV-testing has been shown to provide a superior detection of women at risk of cervical (pre)cancer compared to cytology-based screening. However, as most high-risk HPV infections are harmless, additional triage testing of HPV-positive women is necessary to identify those with cervical (pre)cancer. In this paper, we compare the performance, advantages and limitations of clinically relevant available triage strategies for HPV-positive women.Areas covered: Many different colposcopy triage strategies, comprising both microscopy-based and molecular (virus/host-related) markers, have been suggested: Pap cytology, p16/Ki-67 dual-stained cytology, HPV16/18 genotyping, viral DNA methylation and host cell DNA methylation. Literature search was limited to triage strategies that have achieved at least phase 2 of the five-phase framework for biomarker development and studies including large cohorts (≥100 hrHPV-positive women). Triage markers were stratified by sample type (cervical scrape, self-collected sample) and by study population (screening, non-attendee, referral).Expert commentary: At present, repeat Pap cytology and Pap cytology combined with HPV16/18 genotyping are the only triage strategies that have been robustly shown to be ready for implementation. Other strategies such as p16/Ki-67 dual-stained cytology and host cell DNA methylation analysis, with or without additional HPV16/18 genotyping, are attractive options for the near future." @default.
- W2487419409 created "2016-08-23" @default.
- W2487419409 creator A5010117898 @default.
- W2487419409 creator A5028408099 @default.
- W2487419409 creator A5033473414 @default.
- W2487419409 creator A5050340051 @default.
- W2487419409 creator A5056537893 @default.
- W2487419409 creator A5057813082 @default.
- W2487419409 creator A5082492592 @default.
- W2487419409 date "2016-08-05" @default.
- W2487419409 modified "2023-10-17" @default.
- W2487419409 title "Management of high-risk HPV-positive women for detection of cervical (pre)cancer" @default.
- W2487419409 cites W1016544425 @default.
- W2487419409 cites W1485564559 @default.
- W2487419409 cites W1487160248 @default.
- W2487419409 cites W1492665086 @default.
- W2487419409 cites W1537810699 @default.
- W2487419409 cites W1560766227 @default.
- W2487419409 cites W1578545435 @default.
- W2487419409 cites W1713633383 @default.
- W2487419409 cites W1757407923 @default.
- W2487419409 cites W1827976466 @default.
- W2487419409 cites W1913773293 @default.
- W2487419409 cites W1942624055 @default.
- W2487419409 cites W1963744267 @default.
- W2487419409 cites W1966681943 @default.
- W2487419409 cites W1968862478 @default.
- W2487419409 cites W1973716430 @default.
- W2487419409 cites W1980750660 @default.
- W2487419409 cites W1981725818 @default.
- W2487419409 cites W1983381724 @default.
- W2487419409 cites W1997612801 @default.
- W2487419409 cites W1999428377 @default.
- W2487419409 cites W1999746003 @default.
- W2487419409 cites W2006691325 @default.
- W2487419409 cites W2007719019 @default.
- W2487419409 cites W2009082272 @default.
- W2487419409 cites W2011518397 @default.
- W2487419409 cites W2015118037 @default.
- W2487419409 cites W2015924874 @default.
- W2487419409 cites W2015961085 @default.
- W2487419409 cites W2016125363 @default.
- W2487419409 cites W2018429811 @default.
- W2487419409 cites W2020386919 @default.
- W2487419409 cites W2032566695 @default.
- W2487419409 cites W2035072735 @default.
- W2487419409 cites W2036087634 @default.
- W2487419409 cites W2037811667 @default.
- W2487419409 cites W2041200362 @default.
- W2487419409 cites W2050815280 @default.
- W2487419409 cites W2051711587 @default.
- W2487419409 cites W2053646914 @default.
- W2487419409 cites W2054603798 @default.
- W2487419409 cites W2055873569 @default.
- W2487419409 cites W2055889778 @default.
- W2487419409 cites W2058399080 @default.
- W2487419409 cites W2062124341 @default.
- W2487419409 cites W2064830547 @default.
- W2487419409 cites W2070308367 @default.
- W2487419409 cites W2074235033 @default.
- W2487419409 cites W2075748627 @default.
- W2487419409 cites W2077372040 @default.
- W2487419409 cites W2094581205 @default.
- W2487419409 cites W2095250514 @default.
- W2487419409 cites W2096733107 @default.
- W2487419409 cites W2097563497 @default.
- W2487419409 cites W2098491904 @default.
- W2487419409 cites W2098752968 @default.
- W2487419409 cites W2098765233 @default.
- W2487419409 cites W2099451994 @default.
- W2487419409 cites W2100722838 @default.
- W2487419409 cites W2101341125 @default.
- W2487419409 cites W2107446269 @default.
- W2487419409 cites W2111855638 @default.
- W2487419409 cites W2113593874 @default.
- W2487419409 cites W2114212562 @default.
- W2487419409 cites W2114343528 @default.
- W2487419409 cites W2114369349 @default.
- W2487419409 cites W2115240529 @default.
- W2487419409 cites W2116220211 @default.
- W2487419409 cites W2116458357 @default.
- W2487419409 cites W2118144034 @default.
- W2487419409 cites W2120551761 @default.
- W2487419409 cites W2121032725 @default.
- W2487419409 cites W2121732950 @default.
- W2487419409 cites W2127386691 @default.
- W2487419409 cites W2129316684 @default.
- W2487419409 cites W2132384241 @default.
- W2487419409 cites W2132805535 @default.
- W2487419409 cites W2134674929 @default.
- W2487419409 cites W2136236728 @default.
- W2487419409 cites W2137960843 @default.
- W2487419409 cites W2138556740 @default.
- W2487419409 cites W2139736159 @default.
- W2487419409 cites W2140566055 @default.
- W2487419409 cites W2141497495 @default.
- W2487419409 cites W2144119531 @default.
- W2487419409 cites W2144175542 @default.