FRINK Linked Data Fragments server

Matches in SemOpenAlex for { <https://semopenalex.org/work/W2487675594> ?p ?o ?g. }

• W2487675594 abstract "Background— The striated muscle costamere, a multiprotein complex at the boundary between the sarcomere and the sarcolemma, plays an integral role in maintaining striated muscle structure and function. Multiple costamere-associated proteins, such as integrins and integrin-interacting proteins, have been identified and shown to play an increasingly important role in the pathogenesis of human cardiomyopathy. Kindlin-2 is an adaptor protein that binds to the integrin β cytoplasmic tail to promote integrin activation. Genetic deficiency of Kindlin-2 results in embryonic lethality, and knockdown of the Kindlin-2 homolog in Caenorhabditis elegans and Danio rerio suggests that it has an essential role in integrin function and normal muscle structure and function. The precise role of Kindlin-2 in the mammalian cardiac myocyte remains to be determined. Methods and Results— The current studies were designed to investigate the role of Kindlin-2 in the mammalian heart. We generated a series of cardiac myocyte–specific Kindlin-2 knockout mice with excision of the Kindlin-2 gene in either developing or adult cardiac myocytes. We found that mice lacking Kindlin-2 in the early developing heart are embryonic lethal. We demonstrate that deletion of Kindlin-2 at late gestation or in adult cardiac myocytes resulted in heart failure and premature death, which were associated with enlargement of the heart and extensive fibrosis. In addition, integrin β1D protein expression was significantly downregulated in the adult heart. Conclusions— Kindlin-2 is required to maintain integrin β1D protein stability. Postnatal loss of Kindlin-2 from cardiac myocytes leads to progressive heart failure, showing the importance of costameric proteins like Kindlin-2 for homeostasis of normal heart function." @default.
• W2487675594 created "2016-08-23" @default.
• W2487675594 creator A5004237742 @default.
• W2487675594 creator A5010393077 @default.
• W2487675594 creator A5029705326 @default.
• W2487675594 creator A5037087448 @default.
• W2487675594 creator A5039775565 @default.
• W2487675594 creator A5049101165 @default.
• W2487675594 creator A5049238034 @default.
• W2487675594 creator A5053402281 @default.
• W2487675594 creator A5066925471 @default.
• W2487675594 creator A5085935898 @default.
• W2487675594 creator A5087269715 @default.
• W2487675594 creator A5087983572 @default.
• W2487675594 date "2016-08-01" @default.
• W2487675594 modified "2023-10-18" @default.
• W2487675594 title "Postnatal Loss of Kindlin-2 Leads to Progressive Heart Failure" @default.
• W2487675594 cites W1576773659 @default.
• W2487675594 cites W1704531914 @default.
• W2487675594 cites W1964261332 @default.
• W2487675594 cites W1971019443 @default.
• W2487675594 cites W1971103240 @default.
• W2487675594 cites W1996121136 @default.
• W2487675594 cites W2005532545 @default.
• W2487675594 cites W2008369297 @default.
• W2487675594 cites W2013848448 @default.
• W2487675594 cites W2027029136 @default.
• W2487675594 cites W2027785244 @default.
• W2487675594 cites W2028305453 @default.
• W2487675594 cites W2034685620 @default.
• W2487675594 cites W2036272929 @default.
• W2487675594 cites W2037801641 @default.
• W2487675594 cites W2039453220 @default.
• W2487675594 cites W2040095760 @default.
• W2487675594 cites W2050014442 @default.
• W2487675594 cites W2050108686 @default.
• W2487675594 cites W2050476475 @default.
• W2487675594 cites W2050690016 @default.
• W2487675594 cites W2052003710 @default.
• W2487675594 cites W2058624823 @default.
• W2487675594 cites W2060136332 @default.
• W2487675594 cites W2061914106 @default.
• W2487675594 cites W2062609674 @default.
• W2487675594 cites W2064087371 @default.
• W2487675594 cites W2071304271 @default.
• W2487675594 cites W2073364685 @default.
• W2487675594 cites W2076700858 @default.
• W2487675594 cites W2079006323 @default.
• W2487675594 cites W2085648653 @default.
• W2487675594 cites W2095926133 @default.
• W2487675594 cites W2096326270 @default.
• W2487675594 cites W2097381572 @default.
• W2487675594 cites W2104190934 @default.
• W2487675594 cites W2104455432 @default.
• W2487675594 cites W2104633662 @default.
• W2487675594 cites W2113214379 @default.
• W2487675594 cites W2118357046 @default.
• W2487675594 cites W2134208169 @default.
• W2487675594 cites W2138750896 @default.
• W2487675594 cites W2139114177 @default.
• W2487675594 cites W2141603908 @default.
• W2487675594 cites W2148062709 @default.
• W2487675594 cites W2153570571 @default.
• W2487675594 cites W2167033631 @default.
• W2487675594 cites W2169811294 @default.
• W2487675594 cites W2179216392 @default.
• W2487675594 cites W2277501221 @default.
• W2487675594 cites W771030118 @default.
• W2487675594 doi "https://doi.org/10.1161/circheartfailure.116.003129" @default.
• W2487675594 hasPubMedCentralId "https://www.ncbi.nlm.nih.gov/pmc/articles/4979611" @default.
• W2487675594 hasPubMedId "https://pubmed.ncbi.nlm.nih.gov/27502369" @default.
• W2487675594 hasPublicationYear "2016" @default.
• W2487675594 type Work @default.
• W2487675594 sameAs 2487675594 @default.
• W2487675594 citedByCount "34" @default.
• W2487675594 countsByYear W24876755942017 @default.
• W2487675594 countsByYear W24876755942018 @default.
• W2487675594 countsByYear W24876755942019 @default.
• W2487675594 countsByYear W24876755942020 @default.
• W2487675594 countsByYear W24876755942021 @default.
• W2487675594 countsByYear W24876755942022 @default.
• W2487675594 countsByYear W24876755942023 @default.
• W2487675594 crossrefType "journal-article" @default.
• W2487675594 hasAuthorship W2487675594A5004237742 @default.
• W2487675594 hasAuthorship W2487675594A5010393077 @default.
• W2487675594 hasAuthorship W2487675594A5029705326 @default.
• W2487675594 hasAuthorship W2487675594A5037087448 @default.
• W2487675594 hasAuthorship W2487675594A5039775565 @default.
• W2487675594 hasAuthorship W2487675594A5049101165 @default.
• W2487675594 hasAuthorship W2487675594A5049238034 @default.
• W2487675594 hasAuthorship W2487675594A5053402281 @default.
• W2487675594 hasAuthorship W2487675594A5066925471 @default.
• W2487675594 hasAuthorship W2487675594A5085935898 @default.
• W2487675594 hasAuthorship W2487675594A5087269715 @default.
• W2487675594 hasAuthorship W2487675594A5087983572 @default.
• W2487675594 hasBestOaLocation W24876755941 @default.
• W2487675594 hasConcept C104317684 @default.
• W2487675594 hasConcept C126322002 @default.
• W2487675594 hasConcept C145103041 @default.
• W2487675594 hasConcept C147447768 @default.

• next