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• W2487804589 abstract "Scope Orange juice contains flavanones including hesperidin and narirutin, albeit at lower concentrations as compared to orange fruit. Therefore, we compared bioavailability and colonic catabolism of flavanones from orange juice to a 2.4-fold higher dose from fresh oranges. Methods and results Following a randomized two-way cross-over design, 12 healthy subjects consumed a test meal comprising either fresh oranges or pasteurized orange juice, delivering 1774 and 751 μmol of total Citrus flavanones, respectively. Deglucuronidated and desulfated hesperetin, naringenin, and the flavanone catabolites 3-(3′-hydroxy-4′-methoxyphenyl)propionic acid, 3-(3′-hydroxyphenyl)hydracrylic acid, 4-hydroxyhippuric acid, and hippuric acid were quantitated in 24-h urine by UHPLC-MS/MS. Differences in urinary hesperetin excretion were found to be nonsignificant (p = 0.5209) both after consumption of orange fruit (21.6 ± 8.0 μmol) and juice (18.3 ± 7.2 μmol). By analogy, postprandial flavanone catabolite excretions were highly similar between treatments. Excretion of 3-(3′-hydroxy-4′-methoxyphenyl)propionic acid was inversely related to that of hesperetin, illustrating the catabolite/precursor relationship. Conclusion Despite 2.4-fold higher doses, excretion of flavanones from ingested fresh orange fruit did not differ from that following orange juice consumption, possibly due to a saturation of absorption or their entrapment in the fiber-rich matrix of the fruit." @default.
• W2487804589 created "2016-08-23" @default.
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• W2487804589 date "2016-09-12" @default.
• W2487804589 modified "2023-10-15" @default.
• W2487804589 title "Urinary excretion of<i>Citrus</i>flavanones and their major catabolites after consumption of fresh oranges and pasteurized orange juice: A randomized cross-over study" @default.
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• W2487804589 doi "https://doi.org/10.1002/mnfr.201600315" @default.
• W2487804589 hasPubMedCentralId "https://www.ncbi.nlm.nih.gov/pmc/articles/7301357" @default.
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