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- W2487991978 abstract "The mouse is widely used as a system for the study of mammalian development, and many studies have documented the morphological events that occur as tissues first form and become organised in the post-implantation embryo. However, very little is known of the molecular mechanisms that underlie these morphogenetic processes. In large part this ignorance is due to technical problems in studying embryos that are small, relatively inaccessible, and in which systematic genetics is difficult. One approach towards understanding development is to identify and analyse the function of genes that may have roles in the early events of the formation and spatial organisation of tissues. There are three phases to this type of approach; first, to select candidate genes suspected of having potential roles in development; second, to study their expression pattern in order to gain clues as to what process (or processes) they may be involved in; and third, to analyse their function by manipulative experiments guided by knowledge of their normal expression patterns. Below, we will discuss some of the ways that candidate developmental genes have been selected, and their expression patterns studied by in situ hybridisation." @default.
- W2487991978 created "2016-08-23" @default.
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- W2487991978 date "1990-08-31" @default.
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- W2487991978 title "<i>In situ</i> hybridisation in the analysis of genes with potential roles in mouse embryogenesis" @default.
- W2487991978 doi "https://doi.org/10.1017/cbo9780511629051.008" @default.
- W2487991978 hasPublicationYear "1990" @default.
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