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• W2488001185 endingPage "281" @default.
• W2488001185 startingPage "257" @default.
• W2488001185 abstract "Senescence of neural systems is associated with profound alterations in connective anatomy and tissue architecture. Classical neuroimaging has allowed the in vivo examination of these dynamic changes, and prior studies utilizing quantitative methods have revealed many basic principles of cerebral organization across the lifespan. Recent developments in a range of diffusion-weighted imaging (DWI) techniques have provided a significant advance in the neural parameters available for the in vivo examination of tissue changes across the lifespan. Microstructural measurements produced through diffusion imaging are particularly helpful in charting patterns of alterations in tissue integrity and changes in anatomical connectivity that result from both the typical aging process as well as the myriad of detrimental conditions that increase in incidence with advancing age and affect the nervous system. Diffusion methods may facilitate the measurement of tissue parameters that precede functional or macroscopic structural neural alterations. There is also optimism that the multitude of tissue contrasts that can be extrapolated from diffusion properties may even provide information useful for the specification of different histological degenerative processes that have been documented to occur in older adults. Here we perform a historic review of the literature employing DWI to gain neurobiological insight into the aging brain, as well as work exploring the clinical utility of diffusion imaging towards understanding patterns of age-associated neurodegenerative conditions. We additionally review related concepts, including discussion of the common metrics obtained from diffusion imaging and how lifespan changes in diffusion metrics relate to classically utilized macrostructural volumetric measures. With the great promise of diffusion imaging, it will be critical to continue the advancement of procedures for the acquisition and analysis of diffusion data to increase the specificity and sensitivity of measures of human neuroanatomy and microstructure. In this regard, we review some of the current limitations and challenges in the application of diffusion imaging to address clinical questions, and discuss the great potential for future applications once these challenges are addressed." @default.
• W2488001185 created "2016-08-23" @default.
• W2488001185 creator A5074086023 @default.
• W2488001185 date "2014-01-01" @default.
• W2488001185 modified "2023-09-30" @default.
• W2488001185 title "Diffusion Tensor Imaging in the Study of Aging and Age-Associated Neural Disease" @default.
• W2488001185 cites W1523984875 @default.
• W2488001185 cites W1556823089 @default.
• W2488001185 cites W1963663815 @default.
• W2488001185 cites W1964773137 @default.
• W2488001185 cites W1965730864 @default.
• W2488001185 cites W1966452916 @default.
• W2488001185 cites W1968135525 @default.
• W2488001185 cites W1968323013 @default.
• W2488001185 cites W1968471282 @default.
• W2488001185 cites W1969674465 @default.
• W2488001185 cites W1970932618 @default.
• W2488001185 cites W1971870160 @default.
• W2488001185 cites W1972609121 @default.
• W2488001185 cites W1973127790 @default.
• W2488001185 cites W1974302970 @default.
• W2488001185 cites W1975446567 @default.
• W2488001185 cites W1977103876 @default.
• W2488001185 cites W1978949387 @default.
• W2488001185 cites W1980410848 @default.
• W2488001185 cites W1981027686 @default.
• W2488001185 cites W1981176642 @default.
• W2488001185 cites W1981747783 @default.
• W2488001185 cites W1982198467 @default.
• W2488001185 cites W1983906797 @default.
• W2488001185 cites W1984111997 @default.
• W2488001185 cites W1984167936 @default.
• W2488001185 cites W1984939243 @default.
• W2488001185 cites W1987293003 @default.
• W2488001185 cites W1988287397 @default.
• W2488001185 cites W1988966433 @default.
• W2488001185 cites W1989128216 @default.
• W2488001185 cites W1989653704 @default.
• W2488001185 cites W1990069452 @default.
• W2488001185 cites W1990134753 @default.
• W2488001185 cites W1990620864 @default.
• W2488001185 cites W1992392664 @default.
• W2488001185 cites W1993102117 @default.
• W2488001185 cites W1993637224 @default.
• W2488001185 cites W1994206031 @default.
• W2488001185 cites W1994972002 @default.
• W2488001185 cites W1996189276 @default.
• W2488001185 cites W1997222702 @default.
• W2488001185 cites W1997500882 @default.
• W2488001185 cites W1998594057 @default.
• W2488001185 cites W1999754697 @default.
• W2488001185 cites W2000467078 @default.
• W2488001185 cites W2000547934 @default.
• W2488001185 cites W2001953395 @default.
• W2488001185 cites W2002986520 @default.
• W2488001185 cites W2003902517 @default.
• W2488001185 cites W2004757203 @default.
• W2488001185 cites W2004893182 @default.
• W2488001185 cites W2006716233 @default.
• W2488001185 cites W2007530801 @default.
• W2488001185 cites W2007933561 @default.
• W2488001185 cites W2009036027 @default.
• W2488001185 cites W2009137971 @default.
• W2488001185 cites W2010140396 @default.
• W2488001185 cites W2010617611 @default.
• W2488001185 cites W2012443513 @default.
• W2488001185 cites W2014909648 @default.
• W2488001185 cites W2015766357 @default.
• W2488001185 cites W2015837996 @default.
• W2488001185 cites W2016272003 @default.
• W2488001185 cites W2016813523 @default.
• W2488001185 cites W2018070993 @default.
• W2488001185 cites W2022530159 @default.
• W2488001185 cites W2024199909 @default.
• W2488001185 cites W2027592375 @default.
• W2488001185 cites W2027831798 @default.
• W2488001185 cites W2029436652 @default.
• W2488001185 cites W2029854760 @default.
• W2488001185 cites W2034742899 @default.
• W2488001185 cites W2035351162 @default.
• W2488001185 cites W2037227288 @default.
• W2488001185 cites W2037588444 @default.
• W2488001185 cites W2038568172 @default.
• W2488001185 cites W2039081046 @default.
• W2488001185 cites W2040976452 @default.
• W2488001185 cites W2041632274 @default.
• W2488001185 cites W2043024063 @default.
• W2488001185 cites W2043538065 @default.
• W2488001185 cites W2046132588 @default.
• W2488001185 cites W2047152236 @default.
• W2488001185 cites W2047410266 @default.
• W2488001185 cites W2048188521 @default.
• W2488001185 cites W2050382661 @default.
• W2488001185 cites W2050633133 @default.
• W2488001185 cites W2050873013 @default.
• W2488001185 cites W2051780893 @default.
• W2488001185 cites W2054438774 @default.
• W2488001185 cites W2054612454 @default.

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