Matches in SemOpenAlex for { <https://semopenalex.org/work/W2488002712> ?p ?o ?g. }
- W2488002712 abstract "Abstract Hydrogen sulfide (H 2 S) is an attractive agent for myocardial ischemia-reperfusion injury, however, systemic delivery of H 2 S may cause unwanted side effects. Ultrasound targeted microbubble destruction has become a promising tool for organ specific delivery of bioactive substance. We hypothesized that delivery of H 2 S by ultrasound targeted microbubble destruction attenuates myocardial ischemia-reperfusion injury and could avoid unwanted side effects. We prepared microbubbles carrying hydrogen sulfide (hs-MB) with different H 2 S/C 3 F 8 ratios (4/0, 3/1, 2/2, 1/3, 0/4) and determined the optimal ratio. Release of H 2 S triggered by ultrasound was investigated. The cardioprotective effect of ultrasound targeted hs-MB destruction was investigated in a rodent model of myocardial ischemia-reperfusion injury. The H 2 S/C 3 F 8 ratio of 2/2 was found to be an optimal ratio to prepare stable hs-MB with higher H 2 S loading capability. Ultrasound targeted hs-MB destruction triggered H 2 S release and increased the concentration of H 2 S in the myocardium and lung. Ultrasound targeted hs-MB destruction limited myocardial infarct size, preserved left ventricular function and had no influence on haemodynamics and respiratory. This cardioprotective effect was associated with alleviation of apoptosis and oxidative stress. Delivery of H 2 S to the myocardium by ultrasound targeted hs-MB destruction attenuates myocardial ischemia-reperfusion injury and may avoid unwanted side effects." @default.
- W2488002712 created "2016-08-23" @default.
- W2488002712 creator A5006021560 @default.
- W2488002712 creator A5009775477 @default.
- W2488002712 creator A5016528536 @default.
- W2488002712 creator A5022863735 @default.
- W2488002712 creator A5029741432 @default.
- W2488002712 creator A5040790106 @default.
- W2488002712 creator A5043993720 @default.
- W2488002712 creator A5046031394 @default.
- W2488002712 creator A5054238466 @default.
- W2488002712 creator A5060179467 @default.
- W2488002712 creator A5071958036 @default.
- W2488002712 creator A5072833248 @default.
- W2488002712 creator A5081504678 @default.
- W2488002712 creator A5089116814 @default.
- W2488002712 date "2016-07-29" @default.
- W2488002712 modified "2023-09-30" @default.
- W2488002712 title "Delivery of Hydrogen Sulfide by Ultrasound Targeted Microbubble Destruction Attenuates Myocardial Ischemia-reperfusion Injury" @default.
- W2488002712 cites W1558803026 @default.
- W2488002712 cites W1971253937 @default.
- W2488002712 cites W1977356709 @default.
- W2488002712 cites W1979710206 @default.
- W2488002712 cites W1984798596 @default.
- W2488002712 cites W1989831666 @default.
- W2488002712 cites W1991375427 @default.
- W2488002712 cites W2002208105 @default.
- W2488002712 cites W2009296914 @default.
- W2488002712 cites W2017270842 @default.
- W2488002712 cites W2017604686 @default.
- W2488002712 cites W2018158831 @default.
- W2488002712 cites W2028163170 @default.
- W2488002712 cites W2039503217 @default.
- W2488002712 cites W2043355876 @default.
- W2488002712 cites W2049504582 @default.
- W2488002712 cites W2051395985 @default.
- W2488002712 cites W2056624204 @default.
- W2488002712 cites W2059354318 @default.
- W2488002712 cites W2079153524 @default.
- W2488002712 cites W2088603206 @default.
- W2488002712 cites W2107312159 @default.
- W2488002712 cites W2108485580 @default.
- W2488002712 cites W2108790161 @default.
- W2488002712 cites W2112130225 @default.
- W2488002712 cites W2114712140 @default.
- W2488002712 cites W2116488609 @default.
- W2488002712 cites W2117501559 @default.
- W2488002712 cites W2120464741 @default.
- W2488002712 cites W2126061354 @default.
- W2488002712 cites W2134850908 @default.
- W2488002712 cites W2147137546 @default.
- W2488002712 cites W2152197393 @default.
- W2488002712 cites W2152666077 @default.
- W2488002712 cites W2169505915 @default.
- W2488002712 cites W2169746496 @default.
- W2488002712 cites W2170679758 @default.
- W2488002712 cites W2221246559 @default.
- W2488002712 cites W2317722197 @default.
- W2488002712 cites W2935430241 @default.
- W2488002712 cites W4293084779 @default.
- W2488002712 doi "https://doi.org/10.1038/srep30643" @default.
- W2488002712 hasPubMedCentralId "https://www.ncbi.nlm.nih.gov/pmc/articles/4965795" @default.
- W2488002712 hasPubMedId "https://pubmed.ncbi.nlm.nih.gov/27469291" @default.
- W2488002712 hasPublicationYear "2016" @default.
- W2488002712 type Work @default.
- W2488002712 sameAs 2488002712 @default.
- W2488002712 citedByCount "25" @default.
- W2488002712 countsByYear W24880027122016 @default.
- W2488002712 countsByYear W24880027122017 @default.
- W2488002712 countsByYear W24880027122018 @default.
- W2488002712 countsByYear W24880027122019 @default.
- W2488002712 countsByYear W24880027122020 @default.
- W2488002712 countsByYear W24880027122021 @default.
- W2488002712 countsByYear W24880027122022 @default.
- W2488002712 countsByYear W24880027122023 @default.
- W2488002712 crossrefType "journal-article" @default.
- W2488002712 hasAuthorship W2488002712A5006021560 @default.
- W2488002712 hasAuthorship W2488002712A5009775477 @default.
- W2488002712 hasAuthorship W2488002712A5016528536 @default.
- W2488002712 hasAuthorship W2488002712A5022863735 @default.
- W2488002712 hasAuthorship W2488002712A5029741432 @default.
- W2488002712 hasAuthorship W2488002712A5040790106 @default.
- W2488002712 hasAuthorship W2488002712A5043993720 @default.
- W2488002712 hasAuthorship W2488002712A5046031394 @default.
- W2488002712 hasAuthorship W2488002712A5054238466 @default.
- W2488002712 hasAuthorship W2488002712A5060179467 @default.
- W2488002712 hasAuthorship W2488002712A5071958036 @default.
- W2488002712 hasAuthorship W2488002712A5072833248 @default.
- W2488002712 hasAuthorship W2488002712A5081504678 @default.
- W2488002712 hasAuthorship W2488002712A5089116814 @default.
- W2488002712 hasBestOaLocation W24880027121 @default.
- W2488002712 hasConcept C126838900 @default.
- W2488002712 hasConcept C143753070 @default.
- W2488002712 hasConcept C164705383 @default.
- W2488002712 hasConcept C178790620 @default.
- W2488002712 hasConcept C185592680 @default.
- W2488002712 hasConcept C2780114680 @default.
- W2488002712 hasConcept C2780564542 @default.
- W2488002712 hasConcept C500558357 @default.
- W2488002712 hasConcept C518881349 @default.