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- W2488012334 abstract "The role of trace elements in general, and Mn(II) in particular, has been examined in the metabolism of calcified tissue at several levels. The tissue distribution of 54Mn orally administered to mice was followed. Specific Mn(II) binding sites in the enamel of teeth have been characterized using EPR. Rats on long-term, 12-24 months, dietary regimens depleted in Mn or low Mn-low Cu showed significantly lower bone density and higher serum Ca than controls. The application of ectopic subcutaneous implants of bone powder and demineralized bone powder into animals on control or Mn deplete diets demonstrated that osteoblast activity, a measure of bone formation, was impaired as was osteoclast activity, a parameter of bone resorption. The multiple cellular effects of Mn deficiency include: decreased bone resorption, production of labile bone, and decreased synthesis of organic matrix. The serum level of Mn in a group of osteoporotic postmenopausal women was significantly lower than age-matched controls." @default.
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- W2488012334 date "1987-10-05" @default.
- W2488012334 modified "2023-10-16" @default.
- W2488012334 title "Role of Manganese in Bone Metabolism" @default.
- W2488012334 doi "https://doi.org/10.1021/bk-1987-0354.ch005" @default.
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