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• W2488032946 abstract "Group A Streptococcus (GAS) infections cause substantial worldwide morbidity and mortality, mostly associated with suppurative complications such as pharyngitis, impetigo, and non-suppurative immune syndromes such as acute rheumatic fever, rheumatic heart disease, and acute post-streptococcal glomerulonephritis. Deaths occur mostly in children, adolescents, and young adults in particular pregnant women in low- and middle-income countries. GAS strains are highly variable, and a GAS vaccine would need to overcome the issue of multiple strains. Several approaches have been used multivalent vaccines using N-terminal polypeptides of different M protein; conserved M protein vaccines with antigens from the conserved C-repeat portion of the M protein; incorporation selected T- and B-cell epitopes from the C-repeat region in a synthetic polypeptide or shorter single minimal B-cell epitopes from this same region; and non-M protein approaches utilizing highly conserved motives of streptococcal C5a peptidase, GAS carbohydrate and streptococcal fibronectin-binding proteins. A GAS vaccine represents urgent need for this neglected disease and should therefore deserve the greatest attention of international organizations, donors, and vaccine manufacturers." @default.
• W2488032946 created "2016-08-23" @default.
• W2488032946 creator A5001108158 @default.
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• W2488032946 date "2016-01-01" @default.
• W2488032946 modified "2023-10-16" @default.
• W2488032946 title "Accelerating the development of a group A<i>Streptococcus</i>vaccine: an urgent public health need" @default.
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• W2488032946 doi "https://doi.org/10.7774/cevr.2016.5.2.101" @default.
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