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• W2488115448 abstract "Drug discovery toxicology is a step-wise process that identifies the safety profile of a therapeutic compound from target assessment to candidate nomination. Bone marrow toxicity has traditionally taken a backseat to other common and/or severe organ toxicities during this process. Identifying hematopoietic toxicants and their potency earlier during the drug development process prior to multipleday in vivo toxicology studies has the potential to save considerable time, effort, cost, and animal usage and improve the overall success of the project. The colony-forming cell (CFC) assay has played a defining role in elucidating the hierarchical structure and regulatory mechanisms governing the steady state and perturbed hematopoietic system. Primitive progenitor cells have a higher rate of proliferation, which decreases as the differentiation process increases. Finally, how in vitro hemotoxicity testing can be applied to the drug development pipeline is demonstrated." @default.
• W2488115448 created "2016-08-23" @default.
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• W2488115448 date "2016-03-24" @default.
• W2488115448 modified "2023-09-23" @default.
• W2488115448 title "Predicting Organ ToxicityIn Vitro" @default.
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• W2488115448 doi "https://doi.org/10.1002/9781119053248.ch11" @default.
• W2488115448 hasPublicationYear "2016" @default.
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