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• W2488129280 endingPage "406" @default.
• W2488129280 startingPage "393" @default.
• W2488129280 abstract "The generation of animals from somatic cells by nuclear transfer has taught us that cellular differentiation is reversible and not caused by permanent changes to the genome. Rather, the same genetic information is used to establish different gene expression states and thereby cell types with different physiological functions. Experimental manipulations of gene expression states by nuclear transplantation can provide insights into how cells alter or stably maintain a particular state. An important determinant of the successful transition from a somatic to an embryonic state is the cell cycle stage of oocytes or zygotes at the time of somatic cell nuclear transfer. At interphase, the factors constituting the gene expression program in oocytes or zygotes are associated with chromatin, while in mitosis they localize to the cytoplasm. This physical separation of the genetic information from the major determinants that regulate its expression allows the exchange of the embryonic with a somatic genome, while retaining an embryonic gene expression program. However, embryonic factors can only mediate an efficient transition from somatic to embryonic gene expression if the somatic nucleus is remodeled during cell division and reformed as a nucleus of embryonic morphology at the first interphase after transfer. This suggests that nuclear structure and gene expression are functionally interdependent and require coordinated establishment in a cell type-specific manner during the exit from meiosis or mitosis." @default.
• W2488129280 created "2016-08-23" @default.
• W2488129280 creator A5068085547 @default.
• W2488129280 creator A5086997649 @default.
• W2488129280 date "2014-01-01" @default.
• W2488129280 modified "2023-09-25" @default.
• W2488129280 title "How Cell Division Facilitates Nuclear Reprogramming" @default.
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