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- W2488133793 abstract "Background: High concentrations of nitric oxide (NO) originating from a type-2 nitric oxide synthase (NOS2) located within the paranasal sinuses are measured in nasal air in man. NO is believed to play a central role in nonspecific defense of paranasal sinuses. Glucocorticoids (GCs), a therapeutic often used for a wide range of diseases, is known to strongly downregulate NOS2. Aims of the study: To investigate the effect of very high intravenous doses of GCs on nasal NO in man. Methods: Nasal NO was measured in 15 patients without any history of allergy or chronic airway disorder who were treated for 3 days with a daily dose of 1000 mg methylprednisolone for an exacerbation of multiple sclerosis. Nasal NO was also measured in 30 matched control subjects. Results: In control subjects, the maximal value of nasal NO [mean (SE)] was 233 (8) part per billion (ppb), and did not differ from patients with multiple sclerosis [maximum value: 219 (13) ppb; left nostril: 214 (12) ppb; right nostril: 215 (12) ppb]. After GCs treatment, nasal NO increased in patients [maximum value: 250 (13) ppb (P < 0.0001); left nostril: 249 (12) ppb (P < 0.0001); right nostril: 244 (13) ppb (P < 0.0001)]. Conclusions: We conclude that GCs do not decrease but even increase nasal NO." @default.
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- W2488133793 date "2005-01-01" @default.
- W2488133793 modified "2023-09-22" @default.
- W2488133793 title "Nasal nitric oxide, the guardian of paranasal sinuses, is paradoxically increased by high doses of intravenous" @default.
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