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- W2488178066 abstract "Objectives: To relate preoperative serum CA-125 levels to risk of nodal metastases in women with grade 1 endometrial cancer that was fully surgically staged. Methods: Charts were reviewed to determine all patients with preoperative grade 1 endometrial carcinoma and a serum CA-125 level, undergoing complete surgical staging. Charts were also reviewed for final stage, grade, and site of metastases. All serum CA-125 levels were measured within 3 weeks of definitive surgery. Results: Analysis was completed on 737 patients with grade 1 endometrial cancer. The mean age of the population was 61.9 years (95% CI 61.3–62.4). Extrauterine disease was found in 14.7% of patients and nodal disease in 12.6%. A significant difference in body mass index was seen between those without lymph node metastases (mean 38.7 kg/m2; 95% CI 38.1–39.3) and those having positive nodes (mean 35.3 kg/m2; 95% CI 34.3–36.3) (P < .001). The mean CA-125 level for the cohort was 25.6 mIU/mL (95% CI 22.0–29.2). No patients with preoperative grade 1 disease and CA-125 levels less than 15 mIU/mL (0/239) had nodal disease at surgical staging, whereas 18.7% (93/498) with a CA-125 level greater than 15 mIU/mL had nodal metastases (P < .001). Conclusions: In patients with grade 1 endometrial adenocarcinomas, CA-125 can be used to identify patients who need full surgical staging, with the risk of missing nodal-positive patients being minimal." @default.
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- W2488178066 date "2016-06-01" @default.
- W2488178066 modified "2023-10-05" @default.
- W2488178066 title "CA-125 and grade 1 endometrial cancer: Analyzing the risk of metastases" @default.
- W2488178066 doi "https://doi.org/10.1016/j.ygyno.2016.04.263" @default.
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