FRINK Linked Data Fragments server

Matches in SemOpenAlex for { <https://semopenalex.org/work/W2488197870> ?p ?o ?g. }

• W2488197870 endingPage "2441" @default.
• W2488197870 startingPage "2432" @default.
• W2488197870 abstract "Abstract Resistance to radiotherapy due to insufficient cancer cell death is a significant cause of treatment failure in non–small cell lung cancer (NSCLC). The endogenous caspase-8 inhibitor FLIP is a critical regulator of cell death that is frequently overexpressed in NSCLC and is an established inhibitor of apoptotic cell death induced via the extrinsic death receptor pathway. Apoptosis induced by ionizing radiation (IR) has been considered to be mediated predominantly via the intrinsic apoptotic pathway; however, we found that IR-induced apoptosis was significantly attenuated in NSCLC cells when caspase-8 was depleted using RNA interference (RNAi), suggesting involvement of the extrinsic apoptosis pathway. Moreover, overexpression of wild-type FLIP, but not a mutant form that cannot bind the critical death receptor adaptor protein FADD, also attenuated IR-induced apoptosis, confirming the importance of the extrinsic apoptotic pathway as a determinant of response to IR in NSCLC. Importantly, when FLIP protein levels were downregulated by RNAi, IR-induced cell death was significantly enhanced. The clinically relevant histone deacetylase (HDAC) inhibitors vorinostat and entinostat were subsequently found to sensitize a subset of NSCLC cell lines to IR in a manner that was dependent on their ability to suppress FLIP expression and promote activation of caspase-8. Entinostat also enhanced the antitumor activity of IR in vivo. Therefore, FLIP downregulation induced by HDAC inhibitors is a potential clinical strategy to radiosensitize NSCLC and thereby improve response to radiotherapy. Overall, this study provides the first evidence that pharmacological inhibition of FLIP may improve response of NCSLC to IR. Mol Cancer Ther; 15(10); 2432–41. ©2016 AACR." @default.
• W2488197870 created "2016-08-23" @default.
• W2488197870 creator A5016266460 @default.
• W2488197870 creator A5017072034 @default.
• W2488197870 creator A5024634242 @default.
• W2488197870 creator A5025767314 @default.
• W2488197870 creator A5028641715 @default.
• W2488197870 creator A5031171731 @default.
• W2488197870 creator A5041179742 @default.
• W2488197870 creator A5056258995 @default.
• W2488197870 creator A5058174847 @default.
• W2488197870 creator A5058332475 @default.
• W2488197870 creator A5068876364 @default.
• W2488197870 creator A5073607851 @default.
• W2488197870 creator A5076875343 @default.
• W2488197870 creator A5078841356 @default.
• W2488197870 creator A5079671542 @default.
• W2488197870 creator A5082562331 @default.
• W2488197870 date "2016-10-01" @default.
• W2488197870 modified "2023-10-14" @default.
• W2488197870 title "FLIP: A Targetable Mediator of Resistance to Radiation in Non–Small Cell Lung Cancer" @default.
• W2488197870 cites W1481099429 @default.
• W2488197870 cites W1966130775 @default.
• W2488197870 cites W1975155851 @default.
• W2488197870 cites W1975593978 @default.
• W2488197870 cites W1977658535 @default.
• W2488197870 cites W1997154923 @default.
• W2488197870 cites W1998423564 @default.
• W2488197870 cites W2001119607 @default.
• W2488197870 cites W2006372386 @default.
• W2488197870 cites W2009285670 @default.
• W2488197870 cites W2015362281 @default.
• W2488197870 cites W2018725927 @default.
• W2488197870 cites W2026650308 @default.
• W2488197870 cites W2030814605 @default.
• W2488197870 cites W2032993375 @default.
• W2488197870 cites W2035440305 @default.
• W2488197870 cites W2037195126 @default.
• W2488197870 cites W2042854288 @default.
• W2488197870 cites W2047271635 @default.
• W2488197870 cites W2064862565 @default.
• W2488197870 cites W2066264051 @default.
• W2488197870 cites W2068669225 @default.
• W2488197870 cites W2068751711 @default.
• W2488197870 cites W2069450380 @default.
• W2488197870 cites W2093151035 @default.
• W2488197870 cites W2093916833 @default.
• W2488197870 cites W2112725925 @default.
• W2488197870 cites W2114727688 @default.
• W2488197870 cites W2120626244 @default.
• W2488197870 cites W2120683603 @default.
• W2488197870 cites W2124251607 @default.
• W2488197870 cites W2146399575 @default.
• W2488197870 cites W2148019984 @default.
• W2488197870 cites W2160651627 @default.
• W2488197870 cites W2163357890 @default.
• W2488197870 cites W2170552969 @default.
• W2488197870 cites W2282707216 @default.
• W2488197870 cites W4210372230 @default.
• W2488197870 doi "https://doi.org/10.1158/1535-7163.mct-16-0211" @default.
• W2488197870 hasPubMedId "https://pubmed.ncbi.nlm.nih.gov/27474150" @default.
• W2488197870 hasPublicationYear "2016" @default.
• W2488197870 type Work @default.
• W2488197870 sameAs 2488197870 @default.
• W2488197870 citedByCount "19" @default.
• W2488197870 countsByYear W24881978702017 @default.
• W2488197870 countsByYear W24881978702018 @default.
• W2488197870 countsByYear W24881978702019 @default.
• W2488197870 countsByYear W24881978702020 @default.
• W2488197870 countsByYear W24881978702021 @default.
• W2488197870 countsByYear W24881978702022 @default.
• W2488197870 crossrefType "journal-article" @default.
• W2488197870 hasAuthorship W2488197870A5016266460 @default.
• W2488197870 hasAuthorship W2488197870A5017072034 @default.
• W2488197870 hasAuthorship W2488197870A5024634242 @default.
• W2488197870 hasAuthorship W2488197870A5025767314 @default.
• W2488197870 hasAuthorship W2488197870A5028641715 @default.
• W2488197870 hasAuthorship W2488197870A5031171731 @default.
• W2488197870 hasAuthorship W2488197870A5041179742 @default.
• W2488197870 hasAuthorship W2488197870A5056258995 @default.
• W2488197870 hasAuthorship W2488197870A5058174847 @default.
• W2488197870 hasAuthorship W2488197870A5058332475 @default.
• W2488197870 hasAuthorship W2488197870A5068876364 @default.
• W2488197870 hasAuthorship W2488197870A5073607851 @default.
• W2488197870 hasAuthorship W2488197870A5076875343 @default.
• W2488197870 hasAuthorship W2488197870A5078841356 @default.
• W2488197870 hasAuthorship W2488197870A5079671542 @default.
• W2488197870 hasAuthorship W2488197870A5082562331 @default.
• W2488197870 hasBestOaLocation W24881978701 @default.
• W2488197870 hasConcept C104317684 @default.
• W2488197870 hasConcept C121608353 @default.
• W2488197870 hasConcept C127561419 @default.
• W2488197870 hasConcept C163421366 @default.
• W2488197870 hasConcept C190283241 @default.
• W2488197870 hasConcept C2776055636 @default.
• W2488197870 hasConcept C2776262904 @default.
• W2488197870 hasConcept C2776591724 @default.
• W2488197870 hasConcept C2778305200 @default.

• next