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- W2488258212 abstract "Human parvovirus B19 (B19) is single stranded DNA virus that causes erythema infectinosum in infant and/or acute onset polyarthritis in adult. We present the evidence showing the role of B19 on the etiopathogy of rheumatoid arthritis (RA) . B19 DNA could be frequently amplifi ed in the samples from rheumatoid joints. The detection B19 RNA and B19 protein VP1 was specific for RA and positive at T cells B cells macrophages and follicular dendritic cells in rheumatoid synovium. (2) B19 infection or transduction of B19 NS1gene caused TNFα IL‑6 and IL‑8 production through activating AP1 and AP2 in macrophages or macrophage celll line U937. We also found Ku80 as a novel receptor for B19 on T cells macrophages or erythroblasts. B19 used clathrin on the surface at their cell entry and caused enhanced actin polymerization resulting in the migration of T cells. (3) B19‑transgenic mice became susceptible to type II collagen‑induced polyarthritis that is a model of RA. We also experienced 12 cases who developed RA after acute B19 infection. (4) Half of RA cases had a defective neutralizing ability to B19. Hirosaki Med.J. 59 Supplement:S12―S18,2007" @default.
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- W2488258212 date "2007-11-29" @default.
- W2488258212 modified "2023-09-23" @default.
- W2488258212 title "Human parvovirus B19 and rheumatoid arthritis" @default.
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