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• W2488259462 endingPage "28" @default.
• W2488259462 startingPage "28" @default.
• W2488259462 abstract "Everyone desires healthy and beautiful-looking skin. However, as we age, our skin becomes old due to physiological changes. Reactive oxygen species (ROS) is an important pathogenic factor involved in human aging. Human skin is exposed to ROS generated from both extrinsic sources such as as ultraviolet (UV) light from the sun, and intrinsic sources such as endogenous oxidative metabolism. ROS-mediated oxidative stress damages the collagen-rich extracellular matrix (ECM), the hallmark of skin connective tissue aging. Damage to dermal collagenous ECM weakens the skin’s structural integrity and creates an aberrant tissue microenvironment that promotes age-related skin disorders, such as impaired wound healing and skin cancer development. Here, we review recent advances in our understanding of ROS/oxidative stress and skin connective tissue aging." @default.
• W2488259462 created "2016-08-23" @default.
• W2488259462 creator A5007561071 @default.
• W2488259462 creator A5019337695 @default.
• W2488259462 date "2016-08-05" @default.
• W2488259462 modified "2023-10-14" @default.
• W2488259462 title "Oxidative Stress and Human Skin Connective Tissue Aging" @default.
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• W2488259462 doi "https://doi.org/10.3390/cosmetics3030028" @default.
• W2488259462 hasPublicationYear "2016" @default.
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