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• W2488281607 abstract "Mendelian randomization refers to an analytic approach to assess the causality of an observed association between a modifiable exposure or risk factor and a clinically relevant outcome. It presents a valuable tool, especially when randomized controlled trials to examine causality are not feasible and observational studies provide biased associations because of confounding or reverse causality. These issues are addressed by using genetic variants as instrumental variables for the tested exposure: the alleles of this exposure-associated genetic variant are randomly allocated and not subject to reverse causation. This, together with the wide availability of published genetic associations to screen for suitable genetic instrumental variables make Mendelian randomization a time- and cost-efficient approach and contribute to its increasing popularity for assessing and screening for potentially causal associations. An observed association between the genetic instrumental variable and the outcome supports the hypothesis that the exposure in question is causally related to the outcome. This review provides an overview of the Mendelian randomization method, addresses assumptions and implications, and includes illustrative examples. We also discuss special issues in nephrology, such as inverse risk factor associations in advanced disease, and outline opportunities to design Mendelian randomization studies around kidney function and disease." @default.
• W2488281607 created "2016-08-23" @default.
• W2488281607 creator A5010058481 @default.
• W2488281607 creator A5018242273 @default.
• W2488281607 creator A5071554578 @default.
• W2488281607 creator A5081187562 @default.
• W2488281607 date "2016-08-02" @default.
• W2488281607 modified "2023-10-17" @default.
• W2488281607 title "Mendelian Randomization as an Approach to Assess Causality Using Observational Data" @default.
• W2488281607 cites W1570583414 @default.
• W2488281607 cites W1596038729 @default.
• W2488281607 cites W1866000643 @default.
• W2488281607 cites W1902575419 @default.
• W2488281607 cites W1905058580 @default.
• W2488281607 cites W1950462993 @default.
• W2488281607 cites W1966136030 @default.
• W2488281607 cites W1970049038 @default.
• W2488281607 cites W1972696558 @default.
• W2488281607 cites W1978929390 @default.
• W2488281607 cites W1981189656 @default.
• W2488281607 cites W1988577995 @default.
• W2488281607 cites W1990737871 @default.
• W2488281607 cites W1994501150 @default.
• W2488281607 cites W1998539628 @default.
• W2488281607 cites W2008662928 @default.
• W2488281607 cites W2009187570 @default.
• W2488281607 cites W2009480731 @default.
• W2488281607 cites W2034863097 @default.
• W2488281607 cites W2041182397 @default.
• W2488281607 cites W2041215109 @default.
• W2488281607 cites W2060810507 @default.
• W2488281607 cites W2075145300 @default.
• W2488281607 cites W2079362912 @default.
• W2488281607 cites W2079759773 @default.
• W2488281607 cites W2080225144 @default.
• W2488281607 cites W2081615427 @default.
• W2488281607 cites W2085941424 @default.
• W2488281607 cites W2086038978 @default.
• W2488281607 cites W2090606108 @default.
• W2488281607 cites W2097510503 @default.
• W2488281607 cites W2101031176 @default.
• W2488281607 cites W2101794801 @default.
• W2488281607 cites W2102309722 @default.
• W2488281607 cites W2103783427 @default.
• W2488281607 cites W2104278634 @default.
• W2488281607 cites W2106379479 @default.
• W2488281607 cites W2108525019 @default.
• W2488281607 cites W2111735528 @default.
• W2488281607 cites W2113699335 @default.
• W2488281607 cites W2116205322 @default.
• W2488281607 cites W2116429926 @default.
• W2488281607 cites W2118008714 @default.
• W2488281607 cites W2119906300 @default.
• W2488281607 cites W2121690051 @default.
• W2488281607 cites W2123005049 @default.
• W2488281607 cites W2127065386 @default.
• W2488281607 cites W2127768736 @default.
• W2488281607 cites W2128187921 @default.
• W2488281607 cites W2128736149 @default.
• W2488281607 cites W2130518281 @default.
• W2488281607 cites W2134941001 @default.
• W2488281607 cites W2135147724 @default.
• W2488281607 cites W2137796179 @default.
• W2488281607 cites W2139875520 @default.
• W2488281607 cites W2141115950 @default.
• W2488281607 cites W2141122054 @default.
• W2488281607 cites W2143685991 @default.
• W2488281607 cites W2143901774 @default.
• W2488281607 cites W2145748250 @default.
• W2488281607 cites W2145813488 @default.
• W2488281607 cites W2146022716 @default.
• W2488281607 cites W2146050890 @default.
• W2488281607 cites W2147452548 @default.
• W2488281607 cites W2147841289 @default.
• W2488281607 cites W2150291618 @default.
• W2488281607 cites W2151096860 @default.
• W2488281607 cites W2151355802 @default.
• W2488281607 cites W2151507617 @default.
• W2488281607 cites W2151685786 @default.
• W2488281607 cites W2151872224 @default.
• W2488281607 cites W2151980237 @default.
• W2488281607 cites W2153117775 @default.
• W2488281607 cites W2153533315 @default.
• W2488281607 cites W2153662687 @default.
• W2488281607 cites W2155533485 @default.
• W2488281607 cites W2155827262 @default.
• W2488281607 cites W2162188632 @default.
• W2488281607 cites W2162204400 @default.
• W2488281607 cites W2165019590 @default.
• W2488281607 cites W2165238174 @default.
• W2488281607 cites W2167960476 @default.
• W2488281607 cites W2247997571 @default.
• W2488281607 cites W2265865881 @default.
• W2488281607 cites W2292311686 @default.
• W2488281607 cites W2325761966 @default.
• W2488281607 cites W2330290021 @default.
• W2488281607 cites W2332303329 @default.
• W2488281607 cites W2411709723 @default.

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