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- W2488324607 abstract "This study was designed to elucidate the neuroprotective effect of resveratrol in a mouse model of bilateral common carotid artery occlusion (BCCAO).Sixty male C57BL/6 mice, weighing 20-24 g, were used in our experiments. The mice were randomly assigned into three groups: control group, BCCAO group and BCCAO+Resveratrol group. Neurological score was assessed 24h, 48h, 72h after BCCAO, respectively. Hematoxylin and eosin (H&E) staining, NeuN and TUNEL were performed to detect the neuronal death and survival. The expression of Bcl-2, Bax, caspase-3, and cleaved caspase-3 were also detected to assess the anti-apoptotic effect of resveratrol by Western Blot.Resveratrol significantly improved neurological score in BCCAO mice. Besides, it attenuates neuronal apoptosis via increasing the expression of Bcl-2 and decreasing the expression of Bax, caspase-3, and cleaved caspase-3. Resveratrol promotes neuronal survival in mice subjected to BCCAO.Resveratrol is beneficial in the model of BCCAO, which is associated with its anti-apoptotic effect." @default.
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- W2488324607 date "2015-01-01" @default.
- W2488324607 modified "2023-10-02" @default.
- W2488324607 title "The neuroprotective effects of resveratrol preconditioning in transient global cerebral ischemia-reperfusion in mice" @default.
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- W2488324607 doi "https://doi.org/10.5137/1019-5149.jtn.14195-15.3" @default.
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